Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
PLCG2 and JAK2
Data Source:
HPRD
(in vivo)
PLCG2
JAK2
Description
phospholipase C gamma 2
Janus kinase 2
Image
GO Annotations
Cellular Component
Cytosol
Plasma Membrane
Extracellular Exosome
Euchromatin
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Cytoskeleton
Plasma Membrane
Caveola
Focal Adhesion
Endosome Lumen
Membrane Raft
Postsynapse
Glutamatergic Synapse
Molecular Function
Phosphotyrosine Residue Binding
Phosphatidylinositol Phospholipase C Activity
Phospholipase C Activity
Protein Binding
Phosphorylation-dependent Protein Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Signaling Receptor Binding
Growth Hormone Receptor Binding
Interleukin-12 Receptor Binding
Protein Binding
ATP Binding
Protein C-terminus Binding
Protein Kinase Binding
Heme Binding
Type 1 Angiotensin Receptor Binding
Acetylcholine Receptor Binding
Histone Kinase Activity (H3-Y41 Specific)
SH2 Domain Binding
Histone Binding
Identical Protein Binding
Phosphatidylinositol 3-kinase Binding
Insulin Receptor Substrate Binding
Metal Ion Binding
Peptide Hormone Receptor Binding
Biological Process
Positive Regulation Of Receptor Internalization
Stimulatory C-type Lectin Receptor Signaling Pathway
Follicular B Cell Differentiation
Phosphatidylinositol Biosynthetic Process
Phospholipid Catabolic Process
Positive Regulation Of Epithelial Cell Migration
Wnt Signaling Pathway
Calcium-mediated Signaling
Platelet Activation
B Cell Differentiation
Activation Of Store-operated Calcium Channel Activity
Positive Regulation Of Type I Interferon Production
Response To Lipopolysaccharide
Inositol Trisphosphate Biosynthetic Process
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Negative Regulation Of Programmed Cell Death
Inositol Phosphate Metabolic Process
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Release Of Sequestered Calcium Ion Into Cytosol
MAPK Cascade
Activation Of MAPKK Activity
Microglial Cell Activation
Adaptive Immune Response
Protein Phosphorylation
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Signal Transduction
Enzyme Linked Receptor Protein Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Receptor Signaling Pathway Via JAK-STAT
Tyrosine Phosphorylation Of STAT Protein
Mesoderm Development
Blood Coagulation
Negative Regulation Of Cell Population Proliferation
Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress
Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
Positive Regulation Of Cell-substrate Adhesion
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Peptidyl-tyrosine Phosphorylation
Cytokine-mediated Signaling Pathway
Negative Regulation Of Cell-cell Adhesion
Actin Filament Polymerization
Cell Differentiation
Erythrocyte Differentiation
Positive Regulation Of Cell Migration
Axon Regeneration
Mineralocorticoid Receptor Signaling Pathway
Positive Regulation Of Insulin Secretion
Response To Lipopolysaccharide
Positive Regulation Of Phosphoprotein Phosphatase Activity
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Tumor Necrosis Factor Production
Response To Hydroperoxide
Tumor Necrosis Factor-mediated Signaling Pathway
Response To Tumor Necrosis Factor
Histone H3-Y41 Phosphorylation
Intracellular Signal Transduction
Interleukin-12-mediated Signaling Pathway
Interleukin-23-mediated Signaling Pathway
Positive Regulation Of Protein Import Into Nucleus
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Activation Of Janus Kinase Activity
Regulation Of Apoptotic Process
Positive Regulation Of DNA Binding
Negative Regulation Of DNA Binding
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of MHC Class II Biosynthetic Process
Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of Cell Differentiation
Negative Regulation Of Heart Contraction
Regulation Of Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Ras Protein Signal Transduction
Response To Antibiotic
Protein Autophosphorylation
Platelet-derived Growth Factor Receptor Signaling Pathway
Regulation Of Inflammatory Response
Positive Regulation Of Inflammatory Response
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Modulation Of Chemical Synaptic Transmission
Positive Regulation Of Cell Activation
Positive Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process
Interferon-gamma-mediated Signaling Pathway
Regulation Of Interferon-gamma-mediated Signaling Pathway
Positive Regulation Of SMAD Protein Signal Transduction
Growth Hormone Receptor Signaling Pathway
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Growth Hormone Receptor Signaling Pathway
Mammary Gland Epithelium Development
Interleukin-6-mediated Signaling Pathway
Interleukin-27-mediated Signaling Pathway
Response To Interleukin-12
Interleukin-35-mediated Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
Postsynapse To Nucleus Signaling Pathway
Positive Regulation Of Cold-induced Thermogenesis
Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation
Positive Regulation Of Epithelial Cell Apoptotic Process
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Positive Regulation Of Signaling Receptor Activity
Pathways
GPVI-mediated activation cascade
Toll Like Receptor 4 (TLR4) Cascade
Synthesis of IP3 and IP4 in the cytosol
Generation of second messenger molecules
Role of phospholipids in phagocytosis
DAP12 signaling
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
CLEC7A (Dectin-1) signaling
CLEC7A (Dectin-1) signaling
Dectin-2 family
Dectin-2 family
Erythropoietin activates Phospholipase C gamma (PLCG)
FCGR3A-mediated IL10 synthesis
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Interleukin-6 signaling
Interleukin-6 signaling
MAPK3 (ERK1) activation
MAPK1 (ERK2) activation
Prolactin receptor signaling
Prolactin receptor signaling
Signaling by SCF-KIT
Signaling by Leptin
RMTs methylate histone arginines
Interleukin-3, Interleukin-5 and GM-CSF signaling
Interleukin-3, Interleukin-5 and GM-CSF signaling
RAF activation
RAF/MAP kinase cascade
Interleukin-4 and Interleukin-13 signaling
IL-6-type cytokine receptor ligand interactions
Signaling by moderate kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Cyclin D associated events in G1
Interferon gamma signaling
Regulation of IFNG signaling
Regulation of IFNG signaling
Interleukin-20 family signaling
Interleukin-35 Signalling
Signaling by Erythropoietin
Interleukin-12 signaling
Interleukin-12 signaling
Interleukin-23 signaling
Interleukin-23 signaling
Interleukin-27 signaling
Interleukin-27 signaling
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Erythropoietin activates Phospholipase C gamma (PLCG)
Erythropoietin activates STAT5
Erythropoietin activates RAS
Erythropoietin activates RAS
Interleukin receptor SHC signaling
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Potential therapeutics for SARS
Growth hormone receptor signaling
Growth hormone receptor signaling
Factors involved in megakaryocyte development and platelet production
Drugs
2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one
XL019
5-phenyl-1H-indazol-3-amine
4-(3-amino-1H-indazol-5-yl)-N-tert-butylbenzenesulfonamide
4-[(2-{4-[(CYCLOPROPYLCARBAMOYL)AMINO]-1H-PYRAZOL-3-YL}-1H-BENZIMIDAZOL-6-YL)METHYL]MORPHOLIN-4-IUM
Ruxolitinib
Tofacitinib
Baricitinib
Entrectinib
Fostamatinib
Fedratinib
Zanubrutinib
Pralsetinib
Diseases
Polycythemia vera
GWAS
Alzheimer's disease (late onset) (
28714976
)
Blood protein levels (
30072576
)
Breast cancer (menopausal hormone therapy interaction) (
24080446
)
Ceramide levels (C24:0) (
32489964
)
Coronary artery disease (
29212778
33020668
)
Dental caries (decayed, missing and filled teeth) (
31533690
)
Height (
28552196
)
Inflammatory bowel disease (
28067908
)
Mean platelet volume (
32888494
27863252
)
Metabolite levels (
23823483
)
Platelet count (
32888494
)
Platelet distribution width (
32888494
27863252
)
Reticulocyte count (
32888494
)
Reticulocyte fraction of red cells (
32888494
)
Ulcerative colitis (
28067908
)
Upper eyelid morphology (
29921221
)
Venous thromboembolism (
31420334
31676865
)
Waist-to-hip ratio adjusted for BMI (age >50) (
26426971
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Crohn's disease (
18587394
21102463
23266558
)
Eosinophil counts (
32888494
27863252
)
Eosinophil percentage of white cells (
32888494
)
HDL cholesterol (
30275531
)
Height (
31562340
)
Inflammatory bowel disease (
23128233
)
LDL cholesterol (
30275531
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Monocyte percentage of white cells (
32888494
)
Myeloproliferative neoplasms (
19287384
25849990
33057200
)
Neutrophil count (
32888494
)
Pediatric autoimmune diseases (
26301688
)
Platelet count (
32888494
27863252
24777453
28031487
)
Plateletcrit (
32888494
27863252
)
Psoriatic arthritis (
26626624
)
Red blood cell count (
32888494
)
Sum eosinophil basophil counts (
27863252
)
Systemic lupus erythematosus (
27399966
)
Total cholesterol levels (
30275531
)
Ulcerative colitis (
19915573
26398853
20228799
21297633
)
White blood cell count (
32888494
)
Interacting Genes
56 interacting genes:
AR
ASB9
BLK
BLNK
BTK
CBLB
CD19
DAPP1
EGFR
ELK1
EPOR
EPYC
ERBB2
ERBB3
ERBB4
ESD
FCER1G
FLT1
FYN
GAB1
GAB2
GABPB2
HCK
HSPD1
IRS1
ISL1
ITK
JAK1
JAK2
KCTD17
KDR
KHDRBS1
KIT
LAT
LAT2
LCK
LCP2
LHX8
LIME1
LYN
MET
NPM1
PRKD1
PTPN6
PTTG1
RALBP1
RTL10
SETD9
SH3BP2
SHC1
SYK
TEC
TP53
TWIST2
ZKSCAN7
ZNF512B
97 interacting genes:
ABL1
AGTR1
ARL11
ASS1
BCR
BRCA1
CBL
CCR5
CRLF2
CSF2RB
CSF3R
CTLA4
CXCR4
DNAJA3
EGFR
ELP2
EPOR
ERBB2
ERBB3
EZH2
FES
FYN
GHR
GRB10
GRB2
GTF2I
H3-4
HES1
HES5
HSFY1
HSPA8
HTR2A
IFNGR1
IFNGR2
IGF1R
IKBKG
IL12RB2
IL23R
IL3RA
IL4R
IL5RA
INSR
IRS1
IRS2
JAK3
KIT
LEPR
LYN
MAP3K5
MDK
MPL
MST1R
NFKBIA
OSMR
PDGFRB
PIK3R1
PKD1
PLCG2
PPIA
PPP1CC
PPP2CA
PPP2R1B
PPP2R5A
PRLR
PRMT5
PTK2
PTK2B
PTPN1
PTPN11
PTPN12
PTPN6
PTPRC
RAF1
RBMX
SH2B1
SH2B2
SHC1
SIRPA
SOCS1
SOCS3
STAM
STAM2
STAP2
STAT1
STAT2
STAT3
STAT5A
STAT5B
TEC
TNFRSF1A
TRAF6
TSHR
TUB
UBASH3B
VAV1
VCP
YES1
Entrez ID
5336
3717
HPRD ID
02570
00993
Ensembl ID
ENSG00000197943
ENSG00000096968
Uniprot IDs
P16885
A8K910
B4DYV1
O60674
PDB IDs
2K2J
2W2W
2W2X
2B7A
2W1I
2XA4
3E62
3E63
3E64
3FUP
3IO7
3IOK
3JY9
3KCK
3KRR
3LPB
3Q32
3RVG
3TJC
3TJD
3UGC
3ZMM
4AQC
4BBE
4BBF
4C61
4C62
4D0W
4D0X
4D1S
4E4M
4E6D
4E6Q
4F08
4F09
4FVP
4FVQ
4FVR
4GFM
4GMY
4HGE
4IVA
4JI9
4JIA
4P7E
4YTC
4YTF
4YTH
4YTI
4Z32
4ZIM
5AEP
5CF4
5CF5
5CF6
5CF8
5HEZ
5I4N
5L3A
5TQ3
5TQ4
5TQ5
5TQ6
5TQ7
5TQ8
5USY
5USZ
5UT0
5UT1
5UT2
5UT3
5UT4
5UT5
5UT6
5WEV
5WIJ
5WIK
5WIL
5WIM
5WIN
6AAJ
6BBV
6BRW
6BS0
6BSS
6D2I
6DRW
6E2P
6E2Q
6G3C
6M9H
6OAV
6OBB
6OBF
6OBL
6OCC
6TPD
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?