LRP1B and EVL

Data Source:
BioGRID (affinity chromatography technology)

		LRP1B	EVL
Description		LDL receptor related protein 1B	Enah/Vasp-like
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Receptor Complex	Cytoplasm Cytosol Cytoskeleton Focal Adhesion Membrane Lamellipodium
	Molecular Function	Low-density Lipoprotein Particle Receptor Activity Calcium Ion Binding Protein Binding	Actin Binding Protein Binding Profilin Binding SH3 Domain Binding
	Biological Process	Receptor-mediated Endocytosis Protein Transport	Actin Filament Organization Cell Surface Receptor Signaling Pathway Nervous System Development Axon Guidance Actin Polymerization Or Depolymerization Animal Organ Morphogenesis Negative Regulation Of Epithelial Cell Migration Positive Regulation Of Actin Filament Polymerization Actin Nucleation Protein Homotetramerization Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Ruffle Assembly
Pathways			Generation of second messenger molecules Signaling by ROBO receptors Signaling by ROBO receptors RHO GTPases Activate Formins
Drugs
Diseases
GWAS		Adult body size ( 32376654) Adventurousness ( 30643258) Adverse response to drug ( 30420678) Aging ( 19367585) Asthma (childhood onset) ( 27611488) Blood pressure (smoking interaction) ( 25189868) Body mass index ( 28892062 25673413 20935630) Body size at age 10 ( 32376654) Cerebellum white matter volume ( 31530798) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cognitive performance (processing speed) ( 31598132) Congenital heart disease (inherited effect) ( 28468790) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) Dietary fat liking ( 32516399) Diffusing capacity of carbon monoxide ( 30694715) Diisocyanate-induced asthma ( 25918132) Erectile dysfunction and prostate cancer treatment ( 20932654) Estimated glomerular filtration rate ( 31217584) Facial attractiveness (male raters) ( 30946739) General risk tolerance (MTAG) ( 30643258) Glomerular filtration rate in chronic kidney disease ( 26420894) Hepcidin/ferritin ratio ( 27846281) Household income (MTAG) ( 31844048) Influenza A (H1N1) infection ( 26379185) Lung adenocarcinoma ( 28604730) Menarche (age at onset) ( 21102462 25231870) Mood instability ( 31168069) Motion sickness ( 25628336) Night sleep phenotypes ( 27126917) Number of sexual partners ( 30643258) Optic nerve measurement (disc area) ( 20395239) Peak cortisol response to low dose short synacthen test in corticosteroid treated asthma ( 29551627) Periodontitis (CDC/AAP) ( 24024966) Post bronchodilator FEV1 ( 26634245) Severe influenza A (H1N1) infection ( 26379185) Type 1 diabetes ( 32005708) Type 2 diabetes ( 30130595)	Blood protein levels ( 30072576) White matter hyperintensities ( 32358547) White matter hyperintensity burden ( 25663218)
Interacting Genes		5 interacting genes: APP LRPAP1 PLAT PLAUR SERPINE1	33 interacting genes: ABI1 ABI3 ABL1 APBB1 APBB1IP CRKL DNMBP ENAH FYB1 FYN HCK HTT LYN PFN2 POT1 PRPF40A RAD51 SEMA6A SH3RF1 SPTA1 SPTAN1 SRC TCERG1 TERF1 TES TRIM9 VASP WAS WASL XIRP1 ZDHHC17 ZNF655 ZYX
Entrez ID		53353	51466
HPRD ID		16383	10942
Ensembl ID		ENSG00000168702	ENSG00000196405
Uniprot IDs		Q9NZR2	A0A024R6K5 Q9UI08
PDB IDs
Enriched GO Terms of Interacting Partners?
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