BCL11A and SUZ12

Data Source:
BioGRID (pull down)

		BCL11A	SUZ12
Description		BAF chromatin remodeling complex subunit BCL11A	SUZ12 polycomb repressive complex 2 subunit
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Postsynaptic Density	Nucleus Nucleoplasm Nucleolus Nuclear Body ESC/E(Z) Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Kinase Binding Metal Ion Binding	RNA Polymerase II Transcription Corepressor Binding Protein Binding Chromatin DNA Binding Methylated Histone Binding Histone Methyltransferase Activity Metal Ion Binding Histone Methyltransferase Activity (H3-K27 Specific)
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Gene Expression Protein Sumoylation Negative Regulation Of Dendrite Extension Negative Regulation Of Neuron Remodeling Cellular Response To L-glutamate Negative Regulation Of Dendrite Development Negative Regulation Of Branching Morphogenesis Of A Nerve	Spinal Cord Development Response To Retinoic Acid Negative Regulation Of Chemokine Production Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Cell Differentiation Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of G0 To G1 Transition Histone H3-K27 Trimethylation
Pathways			PRC2 methylates histones and DNA Oxidative Stress Induced Senescence PKMTs methylate histone lysines SUMOylation of chromatin organization proteins Activation of anterior HOX genes in hindbrain development during early embryogenesis Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 HCMV Early Events
Drugs
Diseases
GWAS		Acne (severe) ( 24927181 30542056) Adult body size ( 32376654) Attention deficit hyperactivity disorder ( 22012869) Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027) Beta thalassemia/hemoglobin E disease ( 20183929) Body size at age 10 ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Childhood absence epilepsy ( 30531953) Chronotype ( 30696823) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Endometrial cancer ( 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Epilepsy ( 30531953) F-cell distribution ( 17767159) F-cell distribution in sickle cell anaemia ( 21326311) Face memory ( 31596458) Falling risk ( 32999390) Fetal hemoglobin levels ( 18245381 20018918) Fetal hemoglobin levels in sickle cell anemia ( 25372704) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Generalized epilepsy ( 30531953) Heart rate response to exercise ( 29769521) Heart rate response to recovery post exercise ( 29769521) Heel bone mineral density ( 30598549) Hemoglobin A2 levels in sickle cell anemia ( 25042611) Hemoglobin levels ( 26366553) High fetal hemoglobin in sickle cell disease ( 27022141) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Household income (MTAG) ( 31844048) Hypersomnia (HLA-DQB1*06:02 negative) ( 23646285) Immature fraction of reticulocytes ( 32888494 27863252) Intelligence (MTAG) ( 29326435) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252 28017375 19862010) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Menarche (age at onset) ( 25231870) Methadone dose in opioid dependence ( 28115739) Monocyte early outgrowth colony forming units ( 21493818) Morning person ( 30696823) Number of sexual partners ( 30643258) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Prostate-specific antigen levels ( 30410027 28139693) Red blood cell count ( 32888494 27863252) Red blood cell traits ( 23222517) Red cell distribution width ( 32888494 27863252 28957414) Refractive error ( 32231278) Resting heart rate ( 27798624) Risk-taking tendency (4-domain principal component model) ( 30643258) Sickle cell anemia (haemolysis) ( 23406172) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Type 2 diabetes ( 22885922 24509480 29358691 30297969 32499647 20581827 30718926 28869590) Urinary albumin-to-creatinine ratio in diabetes ( 31511532)	High chromosomal aberration frequency (chromosome type) ( 31586183) Hip circumference adjusted for BMI ( 25673412)
Interacting Genes		28 interacting genes: ACTC1 APP BCL6 CDCA3 CDK4 CDK6 EZH2 GMCL2 HDAC1 HDAC2 LMO1 MORF4L2 MTA1 NCK2 NFAM1 NR2E3 NR2F1 NR2F2 NR2F6 PIN1 RBBP4 RBBP7 SIN3A SIRT1 SUZ12 UBE2I YME1L1 ZBTB24	17 interacting genes: AEBP2 BCL11A CDK19 CDK8 CREB1 CTCF EZH2 H1-1 H3-4 LATS2 MED17 MED6 PAXIP1 PJA1 PRDM14 UBE2I WDR77
Entrez ID		53335	23512
HPRD ID		05949	06949
Ensembl ID		ENSG00000119866	ENSG00000178691
Uniprot IDs		D9YZV9 D9YZW0 Q9H165	J3QQW9 Q15022
PDB IDs		5VTB 6KI6 6U9Q	4W2R 5HYN 5IJ7 5IJ8 5LS6 5WAI 5WAK 5WG6 6B3W 6C23 6C24 6NQ3
Enriched GO Terms of Interacting Partners?
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