PLCB3 and FOXE1

Data Source:
HPRD (in vitro)

		PLCB3	FOXE1
Description		phospholipase C beta 3	forkhead box E1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Membrane Protein-containing Complex Postsynaptic Cytosol	Chromatin Nucleus
	Molecular Function	Phosphatidylinositol Phospholipase C Activity Phospholipase C Activity Calcium Ion Binding Protein Binding Calmodulin Binding Cadherin Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Systemic Arterial Blood Pressure G Protein-coupled Receptor Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway Lipid Catabolic Process Inositol Phosphate Metabolic Process Phosphatidylinositol Metabolic Process Phosphatidylinositol-mediated Signaling	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Thyroid Hormone Generation Anatomical Structure Morphogenesis Cell Migration Cell Differentiation Thyroid Gland Development Hair Follicle Morphogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Thymus Development Embryonic Organ Morphogenesis Hard Palate Development Soft Palate Development Pharynx Development Cranial Skeletal System Development
Pathways		PLC beta mediated events PLC beta mediated events Synthesis of IP3 and IP4 in the cytosol Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion Ca2+ pathway G alpha (q) signalling events G alpha (q) signalling events G beta:gamma signalling through PLC beta Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Presynaptic function of Kainate receptors
Drugs
Diseases			Bamforth-Lazarus syndrome
GWAS		Crohn's disease ( 28067908) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Reticulocyte count ( 32888494) Type 2 diabetes (adjusted for BMI) ( 29632382) Vitiligo ( 27723757) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Alopecia areata ( 25608926) Alzheimer disease and age of onset ( 26830138) Autoimmune thyroid disease ( 32581359) Blond vs. brown/black hair color ( 30531825) Differentiated thyroid cancer ( 28703219) Hyperthyroidism ( 30367059) Hypothyroidism ( 30367059 21981779 27182965 22493691) Obesity-related traits ( 23251661) Orofacial clefts ( 28054174) Papillary thyroid cancer ( 28703219) Parent of origin effect on language impairment (paternal) ( 24571439) Plasma thyroid-stimulating hormone levels ( 28333968) Serum thyroid-stimulating hormone levels ( 24852370 25436638) Thyroid cancer ( 25855579 23894154 19198613) Thyroid cancer (Papillary, radiation-related) ( 20350937) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 25743335)
Interacting Genes		13 interacting genes: CALM3 CAMK2B CAMK2G FOXE1 KRIT1 PARD3 PARD6A PRKG1 PRKG2 RGS12 SLC9A3R2 TRPC3 TRPM7	1 interacting genes: PLCB3
Entrez ID		5331	2304
HPRD ID		02577	04014
Ensembl ID		ENSG00000149782	ENSG00000178919
Uniprot IDs		Q01970	O00358
PDB IDs		3OHM 4GNK 4QJ3 4QJ4 4QJ5
Enriched GO Terms of Interacting Partners?
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