PLA2G5 and GALE

Data Source:
BioGRID (biochemical)

		PLA2G5	GALE
Description		phospholipase A2 group V	UDP-galactose-4-epimerase
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GO Annotations	Cellular Component	Extracellular Region Golgi Apparatus Plasma Membrane Early Phagosome Phagolysosome Recycling Endosome	Cytosol
	Molecular Function	Calcium Ion Binding Phospholipid Binding Calcium-dependent Phospholipase A2 Activity Calcium-independent Phospholipase A2 Activity Phospholipase A2 Activity (consuming 1,2-dipalmitoylphosphatidylcholine) Phospholipase A2 Activity Consuming 1,2-dioleoylphosphatidylethanolamine)	UDP-N-acetylglucosamine 4-epimerase Activity UDP-glucose 4-epimerase Activity Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Fatty Acid Metabolic Process Phospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Positive Regulation Of Phospholipase Activity Positive Regulation Of Macrophage Derived Foam Cell Differentiation Leukotriene Biosynthetic Process Low-density Lipoprotein Particle Remodeling Phosphatidylcholine Catabolic Process Cardiolipin Acyl-chain Remodeling Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylinositol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Phosphatidylethanolamine Acyl-chain Remodeling Arachidonic Acid Secretion Positive Regulation Of Phagocytosis Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Immune Complex Clearance By Monocytes And Macrophages Phagosome-lysosome Fusion Positive Regulation Of Opsonization Positive Regulation Of Antifungal Innate Immune Response Positive Regulation Of Phagosome Maturation	Galactose Catabolic Process Galactose Catabolic Process Via UDP-galactose
Pathways		Acyl chain remodelling of PC Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Synthesis of PA	Defective GALE can cause Epimerase-deficiency galactosemia (EDG) Galactose catabolism
Drugs			Uridine diphosphate glucose Uridine-Diphosphate-N-Acetylgalactosamine UDP-alpha-D-glucuronic acid Tetramethylammonium Uridine-Diphosphate-N-Acetylglucosamine Galactose-uridine-5'-diphosphate
Diseases			Galactosemia
GWAS		Blood protein levels ( 28240269) group IIA secretory phospholipase A2 levels in individuals with elevated hsCRP ( 31070471)
Interacting Genes		1 interacting genes: PLA2G4A	1 interacting genes: APP
Entrez ID		5322	2582
HPRD ID		03117	06092
Ensembl ID		ENSG00000127472	ENSG00000117308
Uniprot IDs		P39877	A0A384NL38 Q14376
PDB IDs		2GHN	1EK5 1EK6 1HZJ 1I3K 1I3L 1I3M 1I3N
Enriched GO Terms of Interacting Partners?
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