KDM3B and RNF41

Data Source:
BioGRID (two hybrid, affinity chromatography technology, proximity labelling technology)

		KDM3B	RNF41
Description		lysine demethylase 3B	ring finger protein 41
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GO Annotations	Cellular Component	Histone Deacetylase Complex Chromatin Nucleoplasm	Cytosol Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Tubular Network
	Molecular Function	Transcription Coregulator Activity Antioxidant Activity Chromatin DNA Binding Histone Demethylase Activity (H3-K9 Specific) Metal Ion Binding Dioxygenase Activity	Ubiquitin-protein Transferase Activity Erythropoietin Receptor Binding Interleukin-3 Receptor Binding Protein Binding Zinc Ion Binding Protein Domain Specific Binding Receptor Tyrosine Kinase Binding Small GTPase Binding Identical Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Histone H3-K9 Demethylation Response To Cisplatin Cellular Oxidant Detoxification	Protein Polyubiquitination Autophagy Negative Regulation Of Cell Population Proliferation Proteasomal Protein Catabolic Process Protein Ubiquitination Negative Regulation Of Cell Migration Regulation Of MAPK Cascade Regulation Of Lymphocyte Differentiation Regulation Of Myeloid Cell Differentiation Positive Regulation Of Protein Catabolic Process Positive Regulation Of DNA-binding Transcription Factor Activity Protein Autoubiquitination Regulation Of Protein Kinase B Signaling Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Mitophagy Regulation Of Establishment Of Cell Polarity Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		HDMs demethylate histones	Downregulation of ERBB2:ERBB3 signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) HIV-1 susceptibility ( 25786224) Menarche (age at onset) ( 21102462 25231870) Response to radiotherapy in prostate cancer (toxicity, urinary frequency) ( 27515689) Schizophrenia ( 25056061)	Asthma ( 31619474)
Interacting Genes		6 interacting genes: CREBBP H3-4 RNF41 SPAG8 UBC ZNF512B	42 interacting genes: ADRB2 AP2S1 APP ARL6IP4 ASB6 BIRC6 C1orf109 ENOPH1 ERBB3 ERBB4 IRS4 ISCA2 KDM3B LEPR LZTS2 MAGEL2 MARK2 MEOX2 MNAT1 MTNR1A MTNR1B MTURN N4BP3 RAD23A RFC4 RNF166 RRM2B SRR TCEANC TRIM32 TRIM8 TSG101 TTC1 UBASH3A UBASH3B UBE2D3 UBE2K UBE2U UBE2Z USP8 VPS52 ZAP70
Entrez ID		51780	10193
HPRD ID		11055	11520
Ensembl ID		ENSG00000120733	ENSG00000181852
Uniprot IDs		Q7LBC6	A0A024RB33 Q9H4P4
PDB IDs		4C8D 5R7X 5RAA 5RAB 5RAC 5RAD 5RAE 5RAF 5RAG 5RAH 5RAI 5RAJ 5RAK 5RAL 5RAM 5RAN 5RAO 5RAP 5RAQ 5RAR 5RAS 5RAU 5RAV 5RAW 5RAX 5RAY 5RAZ 5RB0 5RB1 5RB2 5RB3 5RB4 5RB5 5RB6 5RB7 6RBJ	2FZP 2GWF
Enriched GO Terms of Interacting Partners?
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