RSF1 and ALG8

Data Source:
HPRD (in vitro)

		RSF1	ALG8
Description		remodeling and spacing factor 1	ALG8 alpha-1,3-glucosyltransferase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm RSF Complex	Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Transcription Coregulator Activity Protein Binding ATPase Activity Histone Binding Metal Ion Binding	Alpha-1,3-mannosyltransferase Activity Dolichyl-phosphate-glucose-glycolipid Alpha-glucosyltransferase Activity Protein Binding Dolichyl Pyrophosphate Glc1Man9GlcNAc2 Alpha-1,3-glucosyltransferase Activity
	Biological Process	Nucleosome Assembly Chromatin Remodeling DNA-templated Transcription, Initiation Nucleosome Positioning CENP-A Containing Nucleosome Assembly Negative Regulation Of DNA Binding Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Viral Transcription	Protein N-linked Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process Oligosaccharide-lipid Intermediate Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Mannosylation
Pathways		Deposition of new CENPA-containing nucleosomes at the centromere	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG8 causes ALG8-CDG (CDG-1h)
Drugs
Diseases			Congenital disorders of glycosylation (CDG) type I
GWAS		Left-handedness ( 32989287) Tourette syndrome ( 30818990)	Depression in smokers ( 30219690) Tourette syndrome ( 30818990)
Interacting Genes		3 interacting genes: CSNK2A1 NFKB1 SMARCA5	12 interacting genes: BIK CLRN1 CREB3 CREB3L1 CYB5R3 FAM209A GPX8 LMNA MFSD6 NAE1 RPS6KA5 SAR1A
Entrez ID		51773	79053
HPRD ID		10537	10480
Ensembl ID		ENSG00000048649	ENSG00000159063
Uniprot IDs		Q05DG0 Q96T23	A0A024R5K5 Q9BVK2
PDB IDs
Enriched GO Terms of Interacting Partners?
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