GHRL and GHRHR

Data Source:
HPRD (in vivo)

		GHRL	GHRHR
Description		ghrelin and obestatin prepropeptide	growth hormone releasing hormone receptor
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Axon Secretory Granule Lumen Schaffer Collateral - CA1 Synapse Postsynapse Glutamatergic Synapse	Nuclear Inner Membrane Nuclear Outer Membrane Cytoplasm Plasma Membrane Cell Surface Integral Component Of Membrane Nuclear Matrix Secretory Granule Sarcolemma
	Molecular Function	G Protein-coupled Receptor Binding Protein Binding Growth Hormone-releasing Hormone Activity Protein Tyrosine Kinase Activator Activity Ghrelin Receptor Binding	G Protein-coupled Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Growth Hormone-releasing Hormone Receptor Activity Peptide Hormone Binding Growth Factor Binding
	Biological Process	Activation Of MAPK Activity Gastric Acid Secretion Negative Regulation Of Endothelial Cell Proliferation Glucose Metabolic Process G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Actin Polymerization Or Depolymerization Adult Feeding Behavior Response To Hormone Hormone-mediated Signaling Pathway Dendrite Development Negative Regulation Of Angiogenesis Growth Hormone Secretion Positive Regulation Of Insulin Secretion Regulation Of Response To Food Positive Regulation Of Appetite Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Gastric Emptying Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Growth Rate Negative Regulation Of Locomotion Positive Regulation Of Multicellular Organism Growth Regulation Of Cell Population Proliferation Negative Regulation Of Circadian Sleep/wake Cycle, REM Sleep Negative Regulation Of Apoptotic Process Cortisol Secretion Response To Estrogen Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Insulin Secretion Decidualization Negative Regulation Of Inflammatory Response Cartilage Development Positive Regulation Of Corticotropin Secretion Positive Regulation Of Cortisol Secretion Response To Electrical Stimulus Positive Regulation Of Synapse Assembly Regulation Of Transmission Of Nerve Impulse Excitatory Postsynaptic Potential Positive Regulation Of Growth Hormone Secretion Positive Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Protein Tyrosine Kinase Activity Postsynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Postsynapse Organization Positive Regulation Of Small Intestinal Transit Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Bone Development Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Eating Behavior Positive Regulation Of Adipose Tissue Development Positive Regulation Of Gastric Mucosal Blood Circulation Positive Regulation Of Small Intestine Smooth Muscle Contraction Regulation Of Gastric Motility Positive Regulation Of Vascular Endothelial Cell Proliferation	Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Lactation Positive Regulation Of Cell Population Proliferation Determination Of Adult Lifespan CAMP-mediated Signaling Water Homeostasis Response To Insulin Cellular Response To Insulin Stimulus Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Multicellular Organism Growth Hormone Metabolic Process Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Response To Estrogen Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Cell Maturation Multicellular Organismal Reproductive Process Regulation Of Protein Metabolic Process Response To Glucocorticoid Positive Regulation Of Growth Hormone Secretion Somatotropin Secreting Cell Development Cellular Response To Glucose Stimulus
Pathways			G alpha (s) signalling events Glucagon-type ligand receptors ADORA2B mediated anti-inflammatory cytokines production
Drugs			Sermorelin Tesamorelin
Diseases			Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS		Autism spectrum disorder or schizophrenia ( 28540026)
Interacting Genes		9 interacting genes: ACE2 AGRP GHRHR GHSR LEP MLNR NPY UBQLN1 UBQLN2	3 interacting genes: GHRH GHRL MLNR
Entrez ID		51738	2692
HPRD ID		05638	00748
Ensembl ID		ENSG00000157017	ENSG00000106128
Uniprot IDs		Q9UBU3	A0A090N8Y6 Q02643
PDB IDs		1P7X 6H3E	2XDG
Enriched GO Terms of Interacting Partners?
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