OAZ3 and POMC

Data Source:
BioGRID (two hybrid)

		OAZ3	POMC
Description		ornithine decarboxylase antizyme 3	proopiomelanocortin
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Blood Microparticle	Extracellular Region Extracellular Space Cytoplasm Secretory Granule Secretory Granule Lumen
	Molecular Function	Protein Binding Ornithine Decarboxylase Inhibitor Activity	G Protein-coupled Receptor Binding Signaling Receptor Binding Hormone Activity Protein Binding Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding Type 1 Melanocortin Receptor Binding
	Biological Process	Regulation Of Cellular Amino Acid Metabolic Process Polyamine Biosynthetic Process Spermatogenesis Negative Regulation Of Catalytic Activity Positive Regulation Of Protein Catabolic Process Negative Regulation Of Polyamine Transmembrane Transport	Generation Of Precursor Metabolites And Energy Signal Transduction G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Cell-cell Signaling Regulation Of Blood Pressure Cytokine-mediated Signaling Pathway Regulation Of Appetite Negative Regulation Of Tumor Necrosis Factor Production Cellular Pigmentation Glucose Homeostasis Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Glycogen Metabolic Process Regulation Of Corticosterone Secretion
Pathways		Regulation of ornithine decarboxylase (ODC)	Opioid Signalling Androgen biosynthesis Glucocorticoid biosynthesis G-protein activation Peptide hormone biosynthesis Endogenous sterols Peptide ligand-binding receptors G alpha (s) signalling events G alpha (i) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Interleukin-4 and Interleukin-13 signaling FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes ADORA2B mediated anti-inflammatory cytokines production
Drugs			Loperamide Etorphine Dihydromorphine
Diseases
GWAS		Asthma ( 31619474) Carotid plaque burden ( 28282560) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566)	Body mass index ( 26426971 23669352 20935630) Body mass index (age <50) ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Crohn's disease ( 28067908) Height ( 28552196 23563607 18391951) Inflammatory bowel disease ( 28067908) Obesity ( 23563607) Pubertal anthropometrics ( 23449627) Red vs. brown/black hair color ( 30531825) Type 1 diabetes ( 21980299)
Interacting Genes		16 interacting genes: AZIN1 AZIN2 BLZF1 C1orf94 GGN IKZF3 L3MBTL3 OAZ1 ODC1 POMC POU6F2 REL SMAD1 TEPSIN ZBTB42 ZNF620	28 interacting genes: ABI2 APP ATP6V0D2 BHLHA9 C1orf109 CCDC102B ESRRG FGF10 GLYCTK HDDC2 HLA-DRB3 HSF2BP KLHL42 MC1R MC2R MC3R MC4R MC5R MEP1A MKRN3 NFKBID NRDC NTAQ1 OAZ3 PAM SUOX TXN2 VTN
Entrez ID		51686	5443
HPRD ID		18670	01462
Ensembl ID		ENSG00000143450	ENSG00000115138
Uniprot IDs		A0A0G2JH29 H0Y7Y4 Q9UMX2	P01189
PDB IDs			4XNH 4XPD 4Y49 6TUB
Enriched GO Terms of Interacting Partners?
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