GET4 and NUP85

Data Source:
BioGRID (two hybrid)

		GET4	NUP85
Description		guided entry of tail-anchored proteins factor 4	nucleoporin 85
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GO Annotations	Cellular Component	Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol BAT3 Complex	Kinetochore Condensed Chromosome Kinetochore Nuclear Envelope Nucleoplasm Spindle Cytosol Membrane Nuclear Pore Outer Ring Nuclear Membrane Host Cell
	Molecular Function	Protein Binding Chaperone Binding	Protein Binding Structural Constituent Of Nuclear Pore
	Biological Process	Protein Insertion Into ER Membrane Cytoplasmic Sequestering Of Protein Tail-anchored Membrane Protein Insertion Into ER Membrane Maintenance Of Unfolded Protein Involved In ERAD Pathway	Regulation Of Glycolytic Process MRNA Export From Nucleus TRNA Export From Nucleus Protein Import Into Nucleus Viral Process Protein Sumoylation Viral Transcription Lamellipodium Assembly Positive Regulation Of Transcription, DNA-templated Macrophage Chemotaxis Regulation Of Gene Silencing By MiRNA Nephron Development Intracellular Transport Of Virus Regulation Of Cellular Response To Heat
Pathways		Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	ISG15 antiviral mechanism Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs snRNP Assembly Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) RHO GTPases Activate Formins tRNA processing in the nucleus Mitotic Prometaphase HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation Postmitotic nuclear pore complex (NPC) reformation EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		PR interval ( 32439900)	Systemic sclerosis ( 31672989)
Interacting Genes		29 interacting genes: AKT1 ATP5PD BAG6 C1orf109 CAPNS1 CDKN1A CEP126 DUSP21 EEF1G ENKD1 FBN1 FLYWCH2 GET3 GIT2 KAT5 KIFC2 KRTAP9-3 NUP85 PLK1 PRKAB2 PRKCSH PTMS SDCBP SEC61B SNCAIP SOD2 TMEM256 TTR UBAC2	6 interacting genes: DYNC1LI1 EEF1G GET4 PIK3R1 PRKACA VIM
Entrez ID		51608	79902
HPRD ID		12909	01363
Ensembl ID		ENSG00000239857	ENSG00000125450
Uniprot IDs		Q7L5D6	J3KT10 Q9BW27
PDB IDs		6AU8	5A9Q
Enriched GO Terms of Interacting Partners?
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