PDE8A and SEC11A

Data Source:
BioGRID (affinity chromatography technology)

		PDE8A	SEC11A
Description		phosphodiesterase 8A	SEC11 homolog A, signal peptidase complex subunit
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Extracellular Exosome	Signal Peptidase Complex Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Kinase Binding Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity
	Biological Process	Positive Regulation Of Protein Phosphorylation CAMP Catabolic Process Regulation Of Transcription, DNA-templated Signal Transduction G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Cell Death Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of Hydrogen Peroxide-induced Cell Death	Signal Peptide Processing
Pathways		G alpha (s) signalling events	SRP-dependent cotranslational protein targeting to membrane Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Synthesis, secretion, and deacylation of Ghrelin
Drugs		Caffeine 3-isobutyl-1-methyl-7H-xanthine Trapidil
Diseases
GWAS		Bulimia nervosa ( 23568457) Central corneal thickness ( 20719862) Heel bone mineral density ( 30598549) Height ( 31562340) Medication use (diuretics) ( 31015401) Neurofibrillary tangles ( 31497858) Systolic blood pressure ( 30224653 30578418) Testicular germ cell tumor ( 28604728)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Response to ketamine in bipolar disorder or major depression (antidepressant effects) ( 30552317) Schizophrenia ( 29483656)
Interacting Genes			5 interacting genes: ADAM33 BCHE CSNK2B NUPR1 SLC35F6
Entrez ID		5151	23478
HPRD ID		09114	07503
Ensembl ID		ENSG00000073417	ENSG00000140612
Uniprot IDs		A0A024RC53 O60658	A0A024RC78 H0YKT4 P67812
PDB IDs		1LHQ 1LXX 3ECM 3ECN
Enriched GO Terms of Interacting Partners?
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