EVL and KRT17

Data Source:
BioGRID (proximity labelling technology)

		EVL	KRT17
Description		Enah/Vasp-like	keratin 17
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Focal Adhesion Membrane Lamellipodium	Cytosol Intermediate Filament Intermediate Filament Cytoskeleton Cell Periphery
	Molecular Function	Actin Binding Protein Binding Profilin Binding SH3 Domain Binding	Structural Molecule Activity Protein Binding
	Biological Process	Actin Filament Organization Cell Surface Receptor Signaling Pathway Nervous System Development Axon Guidance Actin Polymerization Or Depolymerization Animal Organ Morphogenesis Negative Regulation Of Epithelial Cell Migration Positive Regulation Of Actin Filament Polymerization Actin Nucleation Protein Homotetramerization Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Ruffle Assembly	Positive Regulation Of Cell Growth Hair Follicle Morphogenesis Keratinization Intermediate Filament Organization Positive Regulation Of Translation Positive Regulation Of Hair Follicle Development Cornification
Pathways		Generation of second messenger molecules Signaling by ROBO receptors Signaling by ROBO receptors RHO GTPases Activate Formins	Keratinization Formation of the cornified envelope
Drugs
Diseases			Pachyonychia congenita, including: Jadassohn-Lewandowsky syndrome; Jackson-Lawler syndrome ; Steatocystoma multiplex
GWAS		Blood protein levels ( 30072576) White matter hyperintensities ( 32358547) White matter hyperintensity burden ( 25663218)
Interacting Genes		33 interacting genes: ABI1 ABI3 ABL1 APBB1 APBB1IP CRKL DNMBP ENAH FYB1 FYN HCK HTT LYN PFN2 POT1 PRPF40A RAD51 SEMA6A SH3RF1 SPTA1 SPTAN1 SRC TCERG1 TERF1 TES TRIM9 VASP WAS WASL XIRP1 ZDHHC17 ZNF655 ZYX	11 interacting genes: APC CCDC85B EGFR HRAS KDM1A KRT6A KRT7 KRT72 SNAPIN TRIM69 ZDHHC17
Entrez ID		51466	3872
HPRD ID		10942	01019
Ensembl ID		ENSG00000196405	ENSG00000128422
Uniprot IDs		A0A024R6K5 Q9UI08	Q04695 Q14666
PDB IDs
Enriched GO Terms of Interacting Partners?
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