POLK and REV1

Data Source:
HPRD (in vitro)

		POLK	REV1
Description		DNA polymerase kappa	REV1 DNA directed polymerase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Body Site Of DNA Damage	Nucleoplasm
	Molecular Function	Damaged DNA Binding DNA-directed DNA Polymerase Activity Metal Ion Binding	Damaged DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Deoxycytidyl Transferase Activity Metal Ion Binding
	Biological Process	DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Nucleotide-excision Repair, DNA Gap Filling Cellular Response To DNA Damage Stimulus Translesion Synthesis Nucleotide-excision Repair, DNA Incision Cellular Response To UV Error-prone Translesion Synthesis	DNA Replication Response To UV Translesion Synthesis Error-prone Translesion Synthesis Error-free Translesion Synthesis
Pathways		Translesion synthesis by POLK Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER	Translesion synthesis by REV1 Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis
Drugs		1,2,3-TRIHYDROXY-1,2,3,4-TETRAHYDROBENZO[A]PYRENE 1-[2-DEOXYRIBOFURANOSYL]-2,4-DIFLUORO-5-METHYL-BENZENE-5'MONOPHOSPHATE 2'-deoxy-N-(naphthalen-1-ylmethyl)guanosine 5'-(dihydrogen phosphate)
Diseases
GWAS		Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Iron status biomarkers (transferrin saturation) ( 28334935)	Bipolar disorder ( 21926972)
Interacting Genes		5 interacting genes: PCNA RAD18 REV1 TRAIP WRN	13 interacting genes: CLK1 FAAP20 FHL2 MAD2L2 POLD3 POLDIP2 POLH POLI POLK POLL REV3L TSC22D2 UBC
Entrez ID		51426	51455
HPRD ID		09291	16202
Ensembl ID		ENSG00000122008	ENSG00000135945
Uniprot IDs		A0A024RAP4 Q9UBT6	Q49AI5 Q9UBZ9
PDB IDs		1T94 2LSI 2OH2 2W7O 2W7P 3IN5 3PZP 4BA9 4GK5 4U6P 4U7C 5T14 5W2A 5W2C 6BRX 6BS1 6CST	2EBW 2LSI 2LSK 2LSY 2N1G 3GQC 3VU7 4BA9 4EXT 4GK0 4GK5 5VZM 6ASR 6AXD
Enriched GO Terms of Interacting Partners?
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