CRLF3 and APPL2

Data Source:
BioGRID (two hybrid)

		CRLF3	APPL2
Description		cytokine receptor like factor 3	adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane	Ruffle Nucleus Endosome Plasma Membrane Endosome Membrane Membrane Cytoplasmic Vesicle Early Endosome Membrane Vesicle Early Phagosome Ruffle Membrane Early Phagosome Membrane Macropinosome Extracellular Exosome
	Molecular Function	DNA Binding Protein Binding Identical Protein Binding	Phosphatidylserine Binding Protein Binding Phosphatidylinositol Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Growth Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Cycle Arrest	Diet Induced Thermogenesis Protein Import Into Nucleus Cell Cycle Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Cold Acclimation Regulation Of Fibroblast Migration Signaling Adiponectin-activated Signaling Pathway Regulation Of Toll-like Receptor 4 Signaling Pathway Cellular Response To Hepatocyte Growth Factor Stimulus Glucose Homeostasis Regulation Of Innate Immune Response Negative Regulation Of Fatty Acid Oxidation Negative Regulation Of Glucose Import Negative Regulation Of Neurogenesis Protein Homotetramerization Positive Regulation Of Phagocytosis, Engulfment Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Cellular Response To Insulin Stimulus Positive Regulation Of Macropinocytosis Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Neural Precursor Cell Proliferation
Pathways
Drugs
Diseases
GWAS		Birth weight ( 27680694) Chronic obstructive pulmonary disease ( 30804561) Height ( 28552196 18391951) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 29403010) Platelet distribution width ( 32888494)	Mosquito bite size ( 28199695)
Interacting Genes		10 interacting genes: APPL2 DDIT4L KCTD21 KDM1A L3MBTL3 LGALS14 MYOZ3 RBM14 VPS25 ZFP1	29 interacting genes: APPL1 ATF3 CNMD CRADD CRBN CRLF3 DOK3 EPM2AIP1 KIFC3 KMT2C LDHAL6B LGALS9C LINC02875 LIX1 MLST8 MTA2 PINK1 POT1 PRR35 RAB22A RAB5A RAB5C RAI2 RBBP7 RBP7 RUVBL2 SUV39H2 TINF2 TSC1
Entrez ID		51379	55198
HPRD ID		16757	06945
Ensembl ID		ENSG00000176390	ENSG00000136044
Uniprot IDs		Q8IUI8	Q8NEU8
PDB IDs			4H8S 5C5B
Enriched GO Terms of Interacting Partners?
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