TAOK3 and ERN1

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		TAOK3	ERN1
Description		TAO kinase 3	endoplasmic reticulum to nucleus signaling 1
Image
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane	Nuclear Inner Membrane Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane Ire1 Complex AIP1-IRE1 Complex IRE1-TRAF2-ASK1 Complex IRE1-RACK1-PP2A Complex
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Kinase Inhibitor Activity Protein Binding ATP Binding Transferase Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity	Magnesium Ion Binding Endoribonuclease Activity Protein Serine/threonine Kinase Activity Platelet-derived Growth Factor Receptor Binding Protein Binding ATP Binding Enzyme Binding Hsp70 Protein Binding Identical Protein Binding Protein Homodimerization Activity ADP Binding Unfolded Protein Binding Hsp90 Protein Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	MAPK Cascade DNA Repair Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Cellular Response To DNA Damage Stimulus Mitotic G2 DNA Damage Checkpoint Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of JUN Kinase Activity Negative Regulation Of JNK Cascade Positive Regulation Of JNK Cascade Protein Autophosphorylation Neuron Projection Morphogenesis	Endothelial Cell Proliferation MRNA Cleavage MRNA Catabolic Process Protein Phosphorylation Cell Cycle Arrest Activation Of JUN Kinase Activity Regulation Of Macroautophagy Positive Regulation Of RNA Splicing Cellular Response To Unfolded Protein Response To Endoplasmic Reticulum Stress Cellular Response To Vascular Endothelial Growth Factor Stimulus Peptidyl-serine Autophosphorylation IRE1-mediated Unfolded Protein Response Protein Autophosphorylation MRNA Splicing, Via Endonucleolytic Cleavage And Ligation Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Hydrogen Peroxide Cellular Response To Glucose Stimulus RNA Phosphodiester Bond Hydrolysis, Endonucleolytic MRNA Cleavage Involved In MRNA Processing Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Insulin Metabolic Process Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Peptidyl-serine Trans-autophosphorylation
Pathways			IRE1alpha activates chaperones IRE1alpha activates chaperones
Drugs		Fostamatinib	N~2~-1H-benzimidazol-5-yl-N~4~-(3-cyclopropyl-1H-pyrazol-5-yl)pyrimidine-2,4-diamine Fostamatinib
Diseases
GWAS		Glucose homeostasis traits ( 25524916) Hip circumference ( 28552196) Loneliness ( 31518406) Morphine dose requirement in tonsillectomy and adenoidectomy surgery ( 24909733) Post bronchodilator FEV1 in COPD ( 26634245) Red cell distribution width ( 32888494 27863252) Systemic lupus erythematosus ( 19838195)	Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Liver injury in anti-retroviral drug treated HIV ( 28388302)
Interacting Genes		5 interacting genes: ATF7 ERN1 LRRK2 SMURF1 TRAF2	13 interacting genes: BAK1 BAX COPS5 HSP90AA1 HSPA5 MAP3K5 PSEN1 SRPK2 STUB1 SYVN1 TAOK3 TNFRSF1A TRAF2
Entrez ID		51347	2081
HPRD ID		11620	04943
Ensembl ID		ENSG00000135090	ENSG00000178607
Uniprot IDs		G3V1Q8 Q9H2K8	O75460
PDB IDs		6BDN	2HZ6 3P23 4U6R 4YZ9 4YZC 4YZD 4Z7G 4Z7H 5HGI 6HV0 6HX1 6SHC 6URC
Enriched GO Terms of Interacting Partners?
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