ATP5F1D and EXOSC3

Data Source:
BioGRID (two hybrid)

		ATP5F1D	EXOSC3
Description		ATP synthase F1 subunit delta	exosome component 3
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrial Proton-transporting ATP Synthase Complex, Catalytic Sector F(1) Mitochondrion Mitochondrial Inner Membrane Mitochondrial Proton-transporting ATP Synthase Complex Mitochondrial Matrix	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Transcriptionally Active Chromatin
	Molecular Function	Protein Binding ATP Binding ATPase Activity ADP Binding Proton-transporting ATP Synthase Activity, Rotational Mechanism	3'-5'-exoribonuclease Activity RNA Binding Exoribonuclease Activity Protein Binding
	Biological Process	Oxidative Phosphorylation ATP Biosynthetic Process Aerobic Respiration ATP Synthesis Coupled Proton Transport Mitochondrial Proton-transporting ATP Synthase Complex Assembly Cristae Formation Mitochondrial ATP Synthesis Coupled Proton Transport Response To Copper Ion	Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U4 SnRNA 3'-end Processing Regulation Of MRNA Stability Exonucleolytic Catabolism Of Deadenylated MRNA DNA Deamination Isotype Switching Positive Regulation Of Isotype Switching CUT Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process Nuclear Polyadenylation-dependent TRNA Catabolic Process Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription Polyadenylation-dependent SnoRNA 3'-end Processing
Pathways		Formation of ATP by chemiosmotic coupling Cristae formation	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol
Drugs		Isoflurane Desflurane
Diseases
GWAS
Interacting Genes		10 interacting genes: ATP5F1E EXOSC3 KRTAP10-8 MDFI NBPF19 NOTCH2NLA SRSF11 TRIM55 TRIM63 TTN	9 interacting genes: APP ATP5F1D CDK5RAP1 EXOSC4 EXOSC5 EXOSC9 KHSRP MPHOSPH6 TSR2
Entrez ID		513	51010
HPRD ID		04397	16220
Ensembl ID		ENSG00000099624	ENSG00000107371
Uniprot IDs		P30049	Q9NQT5 Q9NYS3
PDB IDs			2NN6 6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
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