RAPGEFL1 and RAB5C

Data Source:
BioGRID (affinity chromatography technology)

		RAPGEFL1	RAB5C
Description		Rap guanine nucleotide exchange factor like 1	RAB5C, member RAS oncogene family
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GO Annotations	Cellular Component	Membrane	Lysosomal Membrane Endosome Early Endosome Lipid Droplet Plasma Membrane Endomembrane System Endocytic Vesicle Early Endosome Membrane Azurophil Granule Membrane Melanosome Extracellular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity	GTPase Activity Protein Binding GTP Binding GDP Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Nervous System Development Regulation Of Catalytic Activity	Intracellular Protein Transport Endocytosis Regulation Of Endocytosis Neutrophil Degranulation Plasma Membrane To Endosome Transport
Pathways			Golgi Associated Vesicle Biogenesis Neutrophil degranulation TBC/RABGAPs Clathrin-mediated endocytosis RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Asthma ( 31619474) HDL cholesterol levels ( 32203549) Monocyte percentage of white cells ( 32888494) White blood cell count ( 32888494)	Coronary artery disease ( 29212778) Fibrinogen levels ( 28107422 26561523) Mean corpuscular volume ( 32888494) Medication use (thyroid preparations) ( 31015401) Vitiligo ( 27723757) vWF and FVIII levels ( 30586737) White blood cell count ( 32888494)
Interacting Genes		2 interacting genes: APP MLH1	15 interacting genes: ALS2CL APP APPL2 EEA1 ERBB2 GLP1R HRAS INCA1 RABAC1 RBSN RIN2 RIN3 SGSM3 TBC1D15 TBC1D17
Entrez ID		51195	5878
HPRD ID		17954	04947
Ensembl ID		ENSG00000108352	ENSG00000108774
Uniprot IDs		B4DGK9 F5H2D5 Q9UHV5	A0A024R1U4 P51148
PDB IDs		2DHZ	4KYI
Enriched GO Terms of Interacting Partners?
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