ZNF580 and ARHGEF6

Data Source:
BioGRID (two hybrid)

		ZNF580	ARHGEF6
Description		zinc finger protein 580	Rac/Cdc42 guanine nucleotide exchange factor 6
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Cytosol Lamellipodium
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Positive Regulation Of Leukocyte Chemotaxis Regulation Of Transcription By RNA Polymerase II Chemotaxis Inflammatory Response Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Positive Regulation Of Interleukin-8 Production Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Hydrogen Peroxide	Apoptotic Process G Protein-coupled Receptor Signaling Pathway JNK Cascade Lamellipodium Assembly Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways			NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events Regulation of cytoskeletal remodeling and cell spreading by IPP complex components G beta:gamma signalling through CDC42
Drugs
Diseases			Non-syndromic X-linked mental retardation
GWAS			Breast cancer ( 29059683)
Interacting Genes		27 interacting genes: ARHGEF6 BANP CCDC136 CYSRT1 FSD2 GOLGA6L9 HOMEZ IKZF1 KHDRBS3 KRT27 KRT34 KRT40 KRTAP10-7 KRTAP10-8 MDFI MTUS2 NBPF19 NOTCH2NLA PAX9 PSTPIP1 RAD54B SH3GL2 TRIM27 TRIP6 TSC22D4 XBP1 ZNF436	37 interacting genes: ADAM15 ARAP3 ARHGEF7 BMPR1B CAPNS1 CBFA2T3 CCDC33 CDC42 EPHB2 GIT1 GIT2 GOLGA2 GPRASP2 HSF2BP KRT27 NUTM1 PAK1 PAK2 PAK3 PARVB PNMA1 POU6F2 RWDD2A SH2D1A SH3GL3 SIRPA SMAD1 SMAD2 SMAD3 TGFBR1 TGFBR2 TMEM108 TP53BP2 TRAF2 TRIM54 YWHAG ZNF580
Entrez ID		51157	9459
HPRD ID		18353	02226
Ensembl ID		ENSG00000213015	ENSG00000129675
Uniprot IDs		Q9UK33	B7Z3C7 Q15052 Q8N4Q3
PDB IDs			1UJY 1WYR
Enriched GO Terms of Interacting Partners?
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