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IRAK4 and H1-3
Data Source:
BioGRID
(enzymatic study)
IRAK4
H1-3
Description
interleukin 1 receptor associated kinase 4
H1.3 linker histone, cluster member
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Space
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Endosome Membrane
Chromatin
Nucleosome
Euchromatin
Nucleus
Molecular Function
Magnesium Ion Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Interleukin-1 Receptor Binding
Protein Binding
ATP Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Double-stranded DNA Binding
RNA Binding
Chromatin DNA Binding
Nucleosomal DNA Binding
Biological Process
Toll-like Receptor Signaling Pathway
Neutrophil Mediated Immunity
MyD88-dependent Toll-like Receptor Signaling Pathway
Protein Phosphorylation
JNK Cascade
Cytokine-mediated Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Intracellular Signal Transduction
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Innate Immune Response
Positive Regulation Of Smooth Muscle Cell Proliferation
Interleukin-1-mediated Signaling Pathway
Neutrophil Migration
Nucleosome Assembly
Nucleosome Positioning
Chromosome Condensation
Negative Regulation Of Chromatin Silencing
Negative Regulation Of DNA Recombination
Pathways
PIP3 activates AKT signaling
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
IRAK4 deficiency (TLR5)
IRAK4 deficiency (TLR2/4)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Interleukin-1 signaling
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88 dependent cascade initiated on endosome
MyD88 cascade initiated on plasma membrane
Apoptosis induced DNA fragmentation
Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs
1-(3-HYDROXYPROPYL)-2-[(3-NITROBENZOYL)AMINO]-1H-BENZIMIDAZOL-5-YL PIVALATE
Fostamatinib
Diseases
Defects of toll-like receptor signaling, including the following disease: Il-1 receptor-associated kinase 4 (IRAK-4) deficiency
GWAS
Immune reponse to smallpox (secreted TNF-alpha) (
22610502
)
Inflammatory bowel disease (
27569725
)
Interacting Genes
22 interacting genes:
ARNT
EIF4EBP1
H1-1
H1-2
H1-3
H1-4
H1-5
H1-6
IKBKG
IL36RN
IRAK1
MBP
MYD88
PELI1
PELI2
PELI3
TBPL1
TICAM2
TIRAP
TRAF6
TRIM7
ZNF597
7 interacting genes:
CDK1
CDK2
CDK4
EP300
IRAK4
NSD1
PRKCA
Entrez ID
51135
3007
HPRD ID
06051
06764
Ensembl ID
ENSG00000198001
ENSG00000124575
Uniprot IDs
B2RAP9
B4E359
Q69FE3
Q9NWZ3
P16402
PDB IDs
2NRU
2NRY
2O8Y
2OIB
2OIC
2OID
3MOP
4RMZ
4U97
4U9A
4XS2
4Y73
4YO6
4YP8
4ZTL
4ZTM
4ZTN
5K72
5K75
5K76
5K7G
5K7I
5KX7
5KX8
5T1S
5T1T
5UIQ
5UIR
5UIS
5UIT
5UIU
5W84
5W85
6EG9
6EGA
6EGD
6EGE
6EGF
6F3D
6F3E
6F3G
6F3I
6MOM
6N8G
6O8U
6O94
6O95
6O9D
6RFI
6RFJ
6THW
6THX
6THZ
6TI8
6TIA
6UYA
6VQL
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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