ANGPTL4 and FGFR4

Data Source:
BioGRID (two hybrid)

		ANGPTL4	FGFR4
Description		angiopoietin like 4	fibroblast growth factor receptor 4
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Collagen-containing Extracellular Matrix Blood Microparticle	Extracellular Region Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Transport Vesicle Receptor Complex
	Molecular Function	Enzyme Inhibitor Activity Signaling Receptor Binding Protein Binding Identical Protein Binding	Transmembrane Receptor Protein Tyrosine Kinase Activity Fibroblast Growth Factor-activated Receptor Activity Protein Binding ATP Binding Heparin Binding Fibroblast Growth Factor Binding
	Biological Process	Angiogenesis Response To Hypoxia Lipid Metabolic Process Regulation Of Lipid Metabolic Process Negative Regulation Of Apoptotic Process Protein Unfolding Positive Regulation Of Angiogenesis Negative Regulation Of Lipoprotein Lipase Activity Triglyceride Homeostasis Negative Regulation Of Endothelial Cell Apoptotic Process	MAPK Cascade Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Gene Expression Regulation Of Extracellular Matrix Disassembly Cell Migration Peptidyl-tyrosine Phosphorylation Regulation Of Lipid Metabolic Process Positive Regulation Of Kinase Activity Glucose Homeostasis Cholesterol Homeostasis Positive Regulation Of Catalytic Activity Positive Regulation Of Proteolysis Protein Autophosphorylation Positive Regulation Of Protein Kinase B Signaling Phosphate Ion Homeostasis Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Bile Acid Biosynthetic Process Response To Bile Acid Positive Regulation Of DNA Biosynthetic Process
Pathways		PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Assembly of active LPL and LIPC lipase complexes	PI3K Cascade PIP3 activates AKT signaling betaKlotho-mediated ligand binding FGFR4 mutant receptor activation FGFR4 ligand binding and activation Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade; FGFR4 FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 PI-3K cascade:FGFR4 Negative regulation of FGFR4 signaling Signaling by FGFR4 in disease RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs			Heparin Ponatinib Lenvatinib Erdafitinib Pemigatinib
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Coronary artery disease ( 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) HDL cholesterol ( 24097068 28270201 24507774 19060906 30275531 25961943 20686565) HDL cholesterol levels ( 32203549 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolic syndrome ( 31589552) Metabolite levels (lipoprotein measures) ( 27005778) Phospholipid levels in large HDL ( 29084231) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Total cholesterol levels in HDL ( 29084231) Total triglycerides levels ( 29084231) Triglyceride levels ( 32203549 32154731 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 24507774 30275531 25961943 27036123) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Activated partial thromboplastin time ( 22703881) Apolipoprotein A1 levels ( 32203549) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Circulating fibroblast growth factor 23 levels ( 30217807) Height ( 28552196 25282103 31562340) Hemoglobin levels ( 32327693) Hip shape (DXA scan) ( 30320955) Narrowest width of the femoral neck ( 30888730) Nonsyndromic cleft lip ( 31609978) Type 2 diabetes ( 32499647 30718926) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for BMI in smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 26785701 25673412)
Interacting Genes		9 interacting genes: AURKA BRMS1 CASP8 CDKN2A CDKN2C ESR1 FBXW7 FGFR4 TGFB1	83 interacting genes: ABCB5 AKT1 ANGPTL4 ARAF ARNT BECN1 BLID CASC3 CBLC CCND2 CCNE1 CD44 CDH2 CDK4 CDK6 CDKN2A CDKN2B CDKN2C DIRAS3 EPHA2 EPHA4 EPSTI1 ERBB2 ERRFI1 FGF1 FGF17 FGF18 FGF19 FGF2 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FZR1 GLCE GLIS2 GRM1 HGF HIF1A IGF1R KDELR2 LATS2 LRATD2 MAP2K5 MAP2K6 MAP3K5 MAPK14 MDM4 MET MSH2 MTA3 MYC NF2 NSD3 OSGIN1 PDGFRA PDLIM2 PLCG1 PPP3CA PSMC3IP PTPN11 PTPN12 PTPN6 PTPRR RAF1 RASL10B RASSF1 RNF20 ROS1 SCGB3A1 STAT1 STAT3 STK11 TEAD2 TERT THRSP TP53 TSC1 TTYH2 WIF1
Entrez ID		51129	2264
HPRD ID		16173	00625
Ensembl ID		ENSG00000167772	ENSG00000160867
Uniprot IDs		Q9BY76	B4DVP5 J3KPQ0 P22455
PDB IDs		6EUB 6U0A 6U1U 6U73	1QCT 4QQ5 4QQC 4QQJ 4QQT 4QRC 4R6V 4TYE 4TYG 4TYI 4TYJ 4UXQ 4XCU 5JKG 5NUD 5NWZ 5XFF 5XFJ 6IUO 6IUP 6J6Y 6JPE 6JPJ 6NVG 6NVH 6NVI 6NVJ 6NVK 6V9C 6YI8
Enriched GO Terms of Interacting Partners?
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