SH3GLB1 and ICOSLG

Data Source:
BioGRID (unspecified method)

		SH3GLB1	ICOSLG
Description		SH3 domain containing GRB2 like, endophilin B1	inducible T cell costimulator ligand
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GO Annotations	Cellular Component	Golgi Membrane Autophagosome Membrane Cytoplasm Mitochondrial Outer Membrane Cytosol Midbody Cytoplasmic Vesicle Protein-containing Complex	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Cytoplasmic Ribonucleoprotein Granule Extracellular Exosome
	Molecular Function	Protein Binding Lipid Binding Identical Protein Binding Protein Homodimerization Activity Cadherin Binding	Signaling Receptor Binding Protein Binding Identical Protein Binding
	Biological Process	Autophagy Apoptotic Process Positive Regulation Of Autophagy Regulation Of Macroautophagy Positive Regulation Of Protein-containing Complex Assembly Regulation Of Protein Stability Regulation Of Cytokinesis Receptor Catabolic Process Cellular Response To Amino Acid Starvation Cellular Response To Glucose Starvation Autophagic Cell Death Membrane Fission Positive Regulation Of Membrane Tubulation Protein Localization To Vacuolar Membrane Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Autophagosome Assembly	Regulation Of Cytokine Production Adaptive Immune Response Defense Response Hyperosmotic Response Signal Transduction T Cell Costimulation Positive Regulation Of Activated T Cell Proliferation T Cell Activation B Cell Activation T Cell Receptor Signaling Pathway
Pathways			Costimulation by the CD28 family
Drugs
Diseases
GWAS			Ankylosing spondylitis ( 23749187) Blood protein levels ( 30072576 29875488) Celiac disease ( 22057235 20190752) Cerebral amyloid deposition (PET imaging) ( 30361487) Crohn's disease ( 18587394 21102463) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Inflammatory bowel disease ( 23128233) Left ventricular QRS voltage ( 27195777) Rheumatoid arthritis ( 30423114) Type 1 diabetes ( 25751624) Ulcerative colitis ( 21297633)
Interacting Genes		52 interacting genes: ABHD5 ADAM15 ADAM9 AGTRAP AMPH APP ARFIP2 ARHGAP17 BAX BIN1 C1D CACFD1 CDKN2D CMTM5 COQ8A DESI2 DNM2 EXOSC5 F8A1 FAM114A2 FN1 FUNDC1 GADD45A GADD45G GSTP1 HTATIP2 HTT IRGM ITGB1BP2 MAL2 MTA1 PSMA1 RABAC1 RABGGTB RHEX RIC8A SH3GLB2 SH3KBP1 SIN3A SMIM5 SNX1 SNX4 SYNGR3 SYNJ1 SYP TAX1BP1 TFIP11 TPD52 TPD52L2 TTN UBL7 ZNF576	1 interacting genes: ICOS
Entrez ID		51100	23308
HPRD ID		15333	05757
Ensembl ID		ENSG00000097033	ENSG00000160223
Uniprot IDs		A0A087WW40 A0A140VJU5 Q9Y371	A0N0L8 B7Z1W8 O75144
PDB IDs		6UP6 6UPN	6X4G 6X4T
Enriched GO Terms of Interacting Partners?
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