DERA and CIT

Data Source:
BioGRID (affinity chromatography technology)

		DERA	CIT
Description		deoxyribose-phosphate aldolase	citron rho-interacting serine/threonine kinase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Cytosol Secretory Granule Lumen Ficolin-1-rich Granule Lumen	Cytoplasm Cytosol Cytoskeleton Membrane
	Molecular Function	Deoxyribose-phosphate Aldolase Activity Protein Binding	Transcription Coactivator Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding SH3 Domain Binding Protein Kinase Binding PDZ Domain Binding Protein Serine/threonine Kinase Inhibitor Activity Metal Ion Binding Scaffold Protein Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Pentose-phosphate Shunt Deoxyribonucleotide Catabolic Process Carbohydrate Catabolic Process Neutrophil Degranulation Deoxyribonucleoside Catabolic Process Deoxyribose Phosphate Catabolic Process	Mitotic Cell Cycle Mitotic Cytokinesis Peptidyl-threonine Phosphorylation Actomyosin Structure Organization Positive Regulation Of Cytokinesis Negative Regulation Of Hippo Signaling Intracellular Signal Transduction Generation Of Neurons Neuron Apoptotic Process Negative Regulation Of Protein Serine/threonine Kinase Activity
Pathways		Neutrophil degranulation Pentose phosphate pathway	RHO GTPases activate CIT RHO GTPases activate CIT
Drugs			Fostamatinib
Diseases
GWAS		Adverse response to chemotherapy (amenorrhea) in breast cancer ( 31371054) Bone mineral density (hip) and age at menarche ( 26312577) Chronotype ( 30696823) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912)	Number of sexual partners ( 30643258) Urgency urinary incontinence ( 25524241)
Interacting Genes		2 interacting genes: ALDH16A1 HSF2	10 interacting genes: DISC1 DLG4 GRIN1 GRIN2D MTNR1A RAC1 RHOA RHOB RHOC RND3
Entrez ID		51071	11113
HPRD ID		13138	09289
Ensembl ID		ENSG00000023697	ENSG00000122966
Uniprot IDs		E9PPM8 Q9Y315	O14578
PDB IDs
Enriched GO Terms of Interacting Partners?
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