PCK1 and RAE1

Data Source:
BioGRID (affinity chromatography technology)

		PCK1	RAE1
Description		phosphoenolpyruvate carboxykinase 1	ribonucleic acid export 1
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Extracellular Exosome	Fibrillar Center Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Cytoplasm Host Cell Mitotic Spindle Pole
	Molecular Function	Magnesium Ion Binding Phosphoenolpyruvate Carboxykinase (GTP) Activity GTP Binding GDP Binding Manganese Ion Binding Carboxylic Acid Binding Protein Serine Kinase Activity (using GTP As Donor)	RNA Binding Protein Binding Microtubule Binding Ubiquitin Binding
	Biological Process	Glucose Metabolic Process Gluconeogenesis Oxaloacetate Metabolic Process Aging Response To Activity Peptidyl-serine Phosphorylation Propionate Catabolic Process Response To Lipopolysaccharide Response To Insulin Cellular Response To Insulin Stimulus Response To Lipid Glucose Homeostasis Response To Starvation Positive Regulation Of Memory T Cell Differentiation Glycerol Biosynthetic Process From Pyruvate Regulation Of Lipid Biosynthetic Process Cellular Response To Potassium Ion Starvation Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Acidic PH Hepatocyte Differentiation Response To Interleukin-6 Cellular Response To Retinoic Acid Cellular Response To CAMP Cellular Response To Fructose Stimulus Cellular Response To Glucose Stimulus Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Glucagon Stimulus Cellular Response To Hypoxia Cellular Response To Dexamethasone Stimulus Response To Methionine	Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Regulation Of Glycolytic Process RNA Export From Nucleus MRNA Export From Nucleus TRNA Export From Nucleus Cell Cycle Viral Process Protein Sumoylation Viral Transcription Cell Division Regulation Of Mitotic Spindle Organization Regulation Of Gene Silencing By MiRNA Intracellular Transport Of Virus Regulation Of Cellular Response To Heat
Pathways		Abacavir metabolism Transcriptional regulation of white adipocyte differentiation Gluconeogenesis FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis	ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events
Drugs		Phosphoenolpyruvate 1-(2-Fluorobenzyl)-3-Butyl-8-(N-Acetyl-4-Aminobenzyl)-Xanthine 1-Allyl-3-Butyl-8-(N-Acetyl-4-Aminobenzyl)-Xanthine 5'-Guanylylmethylenebisphosphonate
Diseases
GWAS		Emphysema imaging phenotypes ( 26030696) Estimated glomerular filtration rate ( 31152163 31451708) Hematocrit ( 32888494) Hemoglobin ( 32888494) Prudent dietary pattern ( 28644415) Red blood cell count ( 32888494) Response to fenofibrate (adiponectin levels) ( 23149075) Serum alkaline phosphatase levels ( 31666285) Triglycerides ( 30275531) Type 2 diabetes ( 23300278)
Interacting Genes		5 interacting genes: APP C1R FBXO25 IKBKG UBR5	9 interacting genes: BDKRB1 BUB1 DDX24 HTR2B KLRC4 KLRK1 NUMA1 NUP98 NXF1
Entrez ID		5105	8480
HPRD ID		02028	11939
Ensembl ID		ENSG00000124253	ENSG00000101146
Uniprot IDs		P35558	P78406
PDB IDs		1KHB 1KHE 1KHF 1KHG 1M51 1NHX 2GMV	3MMY 4OWR
Enriched GO Terms of Interacting Partners?
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