RNF141 and MVK

Data Source:
BioGRID (two hybrid)

		RNF141	MVK
Description		ring finger protein 141	mevalonate kinase
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GO Annotations	Cellular Component	Membrane	Peroxisome Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding	Magnesium Ion Binding Mevalonate Kinase Activity Protein Binding ATP Binding Identical Protein Binding
	Biological Process	Regulation Of Transcription, DNA-templated Protein Autoubiquitination	Cholesterol Biosynthetic Process Isoprenoid Biosynthetic Process Phosphorylation Isopentenyl Diphosphate Biosynthetic Process, Mevalonate Pathway Regulation Of Cholesterol Biosynthetic Process Negative Regulation Of Inflammatory Response
Pathways			Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP)
Drugs			Farnesyl thiopyrophosphate
Diseases			Mevalonate kinase deficiency; Hyperimmunoglobulinemia D; Mevalonic aciduria
GWAS		Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)	Aspartate aminotransferase levels ( 29403010) Fish- and plant-related diet ( 32066663) HDL cholesterol ( 24097068 18193043 20864672 19060906 30275531 25961943 20686565) HDL cholesterol levels ( 28334899) High density lipoprotein cholesterol levels ( 29403010) Low density lipoprotein cholesterol levels ( 32154731) Mean platelet volume ( 32888494) Neutrophil count ( 29403010) Non-oily fish consumption ( 32066663) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Red cell distribution width ( 28957414)
Interacting Genes		7 interacting genes: DTX3 MAP3K1 MVK PLK3 SMURF1 TRIM24 TRIM8	4 interacting genes: EWSR1 POT1 RNF141 TERF1
Entrez ID		50862	4598
HPRD ID		11509	02015
Ensembl ID		ENSG00000110315	ENSG00000110921
Uniprot IDs		Q8WVD5	B2RDU6 B7Z301 F5H8H2 Q03426
PDB IDs		2ECN 5XEK	2R3V
Enriched GO Terms of Interacting Partners?
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