SPOCK3 and SPOCK2

Data Source:
HPRD (in vitro)

		SPOCK3	SPOCK2
Description		SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3	SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region	Extracellular Matrix
	Molecular Function	Calcium Ion Binding Glycosaminoglycan Binding Metalloendopeptidase Inhibitor Activity	Calcium Ion Binding Protein Binding Glycosaminoglycan Binding Metalloendopeptidase Inhibitor Activity Extracellular Matrix Binding
	Biological Process	Negative Regulation Of Endopeptidase Activity Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan Negative Regulation Of Cell Motility	Synapse Assembly Positive Regulation Of Cell-substrate Adhesion Negative Regulation Of Endopeptidase Activity Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan Extracellular Matrix Organization Regulation Of Cell Differentiation Cellular Response To Leukemia Inhibitory Factor Positive Regulation Of Cell Motility
Pathways		Activation of Matrix Metalloproteinases
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Cognitive function ( 28808816) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Immune reponse to smallpox (secreted IL-10) ( 22610502) Medial orbital frontal cortex volume ( 31530798) Obesity-related traits ( 23251661) Verbal declarative memory ( 25648963) Weight ( 28552196)	Blood protein levels ( 30072576 29875488) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Insulin-like growth factors ( 21216879) Smoking behavior ( 22832964)
Interacting Genes		4 interacting genes: CREB3 MMP14 MMP3 SPOCK2	3 interacting genes: PLXNB3 SPOCK3 TES
Entrez ID		50859	9806
HPRD ID		12147	12146
Ensembl ID		ENSG00000196104	ENSG00000107742
Uniprot IDs		A0A0A0MTJ2 B4DI52 Q9BQ16	A0A024QZQ5 Q92563
PDB IDs
Enriched GO Terms of Interacting Partners?
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