PAX6 and ESRRG

Data Source:
BioGRID (two hybrid)

		PAX6	ESRRG
Description		paired box 6	estrogen related receptor gamma
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol	Chromatin Nucleoplasm
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Kinase Binding Histone Acetyltransferase Binding R-SMAD Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Steroid Hormone Receptor Activity Nuclear Receptor Activity Steroid Binding Protein Binding Zinc Ion Binding AF-2 Domain Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Blood Vessel Development Eye Development Pancreatic A Cell Development Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Visual Perception Response To Wounding Animal Organ Morphogenesis Positive Regulation Of Gene Expression Ventral Spinal Cord Development Glucose Homeostasis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Neuron Fate Commitment Anatomical Structure Development Negative Regulation Of Neurogenesis Iris Morphogenesis Cornea Development In Camera-type Eye Positive Regulation Of Core Promoter Binding	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis
Pathways		Regulation of gene expression in beta cells Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Activation of anterior HOX genes in hindbrain development during early embryogenesis	Nuclear Receptor transcription pathway
Drugs			Troglitazone Diethylstilbestrol Tamoxifen Cholic Acid Afimoxifene 4-HYDROXY-N'-(4-ISOPROPYLBENZYL)BENZOHYDRAZIDE p-Cumylphenol Bisphenol A Bisphenol Z Estradiol acetate Estradiol benzoate Estradiol cypionate Estradiol dienanthate Estradiol valerate
Diseases		Aniridia Polymicrogyria; Bilateral frontal polymicrogyria (BFP); Bilateral frontoparietal polymicrogyria (BFPP); Bilateral perisylvian polymicrogyria (BPP); Bilateral parasagittal parieto-occipital polymicrogyria (BPOP); Bilateral generalised polymicrogyria (BGP); Unilateral Polymicrogyria (ULP) Ocular coloboma, including: Coloboma of iris choroid and retina (COI); Coloboma of optic nerve (COLON)
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Body mass index ( 22344219 28892062) Depression ( 29700475) Diastolic blood pressure ( 27841878) Feeling worry ( 29500382) General factor of neuroticism ( 30867560) Irritable mood ( 29500382) Major depressive disorder ( 27479909) Neurociticism ( 29500382) Optic disc area ( 28073927) Refractive error ( 32231278) Systolic blood pressure ( 27841878)	Adventurousness ( 30643258) Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) ( 23648065) Adverse response to drug ( 30420678) Alcohol consumption ( 23743675) Breast cancer ( 29059683) Cardiac hypertrophy ( 21348951) Cleft lip with or without cleft palate (maternal periconceptional vitamin use interaction) ( 29535761) Depressive symptom (anhedonia) (ordinal trait) ( 31530331) Dialysis-related mortality ( 21546767) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Energy expenditure (24h) ( 28476931) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Gut microbiota relative abundance (Ruminococcus belonging to family Erysipelotrichaceae) ( 33208821) Hematocrit ( 32888494) Hemoglobin ( 32888494) Intelligence (MTAG) ( 29326435) Intracranial aneurysm ( 29531279) Major depressive disorder ( 23377640) Mean arterial pressure (alcohol consumption interaction) ( 24376456) Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Optic nerve measurement (cup area) ( 20395239) Photic sneeze reflex ( 27182965) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Refractive error ( 32231278) Sleep duration ( 25469926) Smoking status (ever vs never smokers) ( 30643258) Tea consumption ( 31046077) Weight ( 28552196)
Interacting Genes		126 interacting genes: ACOT12 AP1M1 ARIH2 ATP6V0D2 ATP6V1C2 BANP BCL2L15 C1orf109 C2CD6 CCDC103 CCDC6 CCL26 CDK3 CDX2 CGGBP1 CHAF1A CIB3 CINP CKS1B CSNK2A1 CTNNA3 CXorf38 DHPS DIAPH1 DLG1 DYNLL1 EAF1 EFHC1 EIF1AD EN1 EP300 ESRRG FAM50B GAS2L2 GCM2 GEMIN2 GPANK1 GRHL2 HGS HIPK2 HMBOX1 HMGB3 HNRNPC HOMER3 HOXA1 HOXB1 HOXC8 HOXC9 IPO13 KANK2 KCTD7 KRTAP9-3 KRTAP9-8 LARP4 LHX2 LNPK LONRF1 LXN LYSMD1 MAFG MAPRE1 MFAP1 MID1 MIPOL1 MISP MITF MORN3 MRPL53 NCDN NFKBID NFYC NGLY1 NKIRAS2 PATJ PBX1 PDE4C PICK1 PIN1 PKNOX1 POLR3C POLR3GL PPIL4 PRKAG1 PROX1 PSORS1C2 QRICH1 RANBP3 RAX RB1 RGS3 RNF111 SAE1 SEC14L4 SET SHANK3 SIGLEC6 SIX3 SLC12A8 SMARCA4 SOX10 SOX3 SPDYC SPG21 SRSF11 STAC SUMO1 TBP TCP11L1 THOC1 TLK1 TLK2 TRAPPC6A TRIM11 TRIP10 UBE2F UBE2K UBE3A UBXN2B UBXN7 USHBP1 VCX2 VSX2 WASHC3 ZBED1 ZNF124 ZNF410	58 interacting genes: ADCY4 APP ARHGEF15 ATM BPHL C22orf23 CALM1 CAMK2G CCDC33 DAXX DEUP1 DUT EBP EFHC2 ESRRA ESRRB EXOSC7 FAM107A FAM9A FASTK HGS HIF1A KIFC3 LRRK2 MCC MEOX2 MFHAS1 MRM1 NCOA1 NR0B1 NR0B2 NRIP1 NUP160 PAX6 PNRC1 PNRC2 POMC PPARGC1A PPARGC1B PROX1 PSMC5 RBIS REL RINT1 SHTN1 SNIP1 SP1 SRA1 SRPK1 SUMO1P1 TLE1 TNNI1 TNNI2 TRERF1 TULP3 UBL7 VAX1 ZNF438
Entrez ID		5080	2104
HPRD ID		06167	04274
Ensembl ID		ENSG00000007372	ENSG00000196482
Uniprot IDs		A0A1W2PRA8 D1KF47 F1T0F8 P26367 Q66SS1	B7Z5E9 C0SQ93 F1D8R5 F1D8R6 P62508
PDB IDs		2CUE 6PAX	1KV6 1TFC 1VJB 2E2R 2EWP 2GP7 2GPO 2GPP 2GPU 2GPV 2P7A 2P7G 2P7Z 2ZAS 2ZBS 2ZKC 5YSO 6A6K 6I61 6I62 6I63 6I64 6I65 6I66 6I67 6K3N 6KNR
Enriched GO Terms of Interacting Partners?
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