PLA2G3 and PVR

Data Source:
BioGRID (two hybrid)

		PLA2G3	PVR
Description		phospholipase A2 group III	PVR cell adhesion molecule
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Centriole Plasma Membrane Recycling Endosome	Extracellular Space Cytoplasm Plasma Membrane Adherens Junction Focal Adhesion Cell Surface Integral Component Of Membrane
	Molecular Function	Metal Ion Binding Calcium-dependent Phospholipase A2 Activity Phospholipase A2 Activity (consuming 1,2-dipalmitoylphosphatidylcholine) Phospholipase A2 Activity Consuming 1,2-dioleoylphosphatidylethanolamine)	Virus Receptor Activity Protein Binding Signaling Receptor Activity Cell Adhesion Molecule Binding
	Biological Process	Acrosome Assembly Production Of Molecular Mediator Involved In Inflammatory Response Phospholipid Metabolic Process Phosphatidylserine Metabolic Process Sperm Axoneme Assembly Negative Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Neuron Projection Development Lipoxygenase Pathway Positive Regulation Of Prostaglandin Biosynthetic Process Positive Regulation Of Prostaglandin Secretion Low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Phosphatidylethanolamine Acyl-chain Remodeling Macrophage Activation Mast Cell Degranulation Negative Regulation Of Neuron Apoptotic Process Phosphatidylethanolamine Metabolic Process Phosphatidylcholine Metabolic Process Phosphatidylglycerol Metabolic Process Phosphatidic Acid Metabolic Process Phosphatidylinositol Metabolic Process Cell Maturation Arachidonic Acid Secretion Cilium Assembly Positive Regulation Of Mast Cell Differentiation Positive Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Amyloid-beta Clearance Positive Regulation Of Histamine Secretion By Mast Cell Regulation Of Endocytic Recycling	Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Adherens Junction Organization Susceptibility To Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Viral Entry Into Host Cell Regulation Of Immune Response Susceptibility To T Cell Mediated Cytotoxicity
Pathways		Acyl chain remodelling of PC Acyl chain remodelling of PE Acyl chain remodelling of PG	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Nectin/Necl trans heterodimerization
Drugs			Sphingosine Myristic acid
Diseases
GWAS		Fish- and plant-related diet ( 32066663) Gut microbiota (beta diversity) ( 27723756) Oily fish consumption ( 32066663) Paclitaxel-induced neuropathy ( 23776197) Pork consumption ( 32066663)	Alzheimer's disease ( 24755620) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Mean platelet volume ( 32888494 27863252) Multiple sclerosis ( 21833088) Multiple sclerosis and HDL levels (pleiotropy) ( 26920376) Platelet distribution width ( 32888494)
Interacting Genes		2 interacting genes: PVR TGFB1I1	69 interacting genes: ADIPOQ ANKRD46 AP1M2 AQP10 BRICD5 C3orf52 CD226 CD47 CD96 CLDN19 CTXN3 CYB561A3 CYHR1 CYSRT1 DYNLT1 DYNLT3 EBP EDDM3B GPRC5D HHATL HOXA1 INSIG2 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP3-1 KRTAP3-3 KRTAP6-3 KRTAP9-3 MFSD11 NBPF19 NECTIN1 NECTIN3 NINJ1 NINJ2 NOTCH2NLA OLFM4 PGA4 PLA2G3 PLP2 PLPP6 RUSF1 SCD SFTPC SLC30A2 SLC35B4 SLC41A2 SMIM1 SNAP47 SYS1 TAS2R19 TIGIT TM6SF2 TMBIM6 TMEM147 TMEM229B TMEM54 TMEM65 TMEM79 TSPO VAMP5 VTN WNK1 ZDHHC15 ZDHHC22 ZFPL1
Entrez ID		50487	5817
HPRD ID		07144	01434
Ensembl ID		ENSG00000100078	ENSG00000073008
Uniprot IDs		Q9NZ20	A0A0A0MSA9 A0A0C4DG49 A8K4I1 P15151
PDB IDs			1DGI 1NN8 3EPC 3EPD 3EPF 3J8F 3J9F 3UDW 3URO 4FQP 6ARQ 6ISC 6O3O
Enriched GO Terms of Interacting Partners?
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