PCSK6 and FLG

Data Source:
HPRD (in vitro)

		PCSK6	FLG
Description		proprotein convertase subtilisin/kexin type 6	filaggrin
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Golgi Lumen Plasma Membrane Cell Surface Membrane Collagen-containing Extracellular Matrix	Cornified Envelope Nucleus Cytosol Intermediate Filament Keratohyalin Granule Cytoplasmic Ribonucleoprotein Granule Collagen-containing Extracellular Matrix
	Molecular Function	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Heparin Binding Nerve Growth Factor Binding	Structural Molecule Activity Calcium Ion Binding Protein Binding Structural Constituent Of Skin Epidermis Transition Metal Ion Binding
	Biological Process	Glycoprotein Metabolic Process Protein Processing Peptide Hormone Processing Regulation Of BMP Signaling Pathway Nerve Growth Factor Processing Nerve Growth Factor Production Secretion By Cell Regulation Of Lipoprotein Lipase Activity Cornification	Multicellular Organism Development Peptide Cross-linking Keratinocyte Differentiation Establishment Of Skin Barrier Cornification
Pathways		Signaling by NODAL NGF processing Formation of the cornified envelope Assembly of active LPL and LIPC lipase complexes	Formation of the cornified envelope
Drugs
Diseases			Ichthyosis vulgaris
GWAS		Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Cytokine levels ( 31679650) Cytokine network levels (multivariate analysis) ( 31679650) Handedness in dyslexia ( 21051773) Height ( 31562340) Inflammatory biomarkers (multivariate analysis) ( 33110245) Platelet-derived growth factor BB levels ( 27989323) Red blood cell count ( 32888494) Relative hand skill in reading disability ( 24068947) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Tuberculosis ( 30713548) Type 2 diabetes ( 30470734)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Asthma ( 31361310 31959851 30929738 32296059 31619474) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma (moderate or severe) ( 30552067) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 23886662 21666691 25574825 26482879) Atopic march ( 26542096) Eating disorders ( 23568457) Eczema ( 31361310) Male-pattern baldness ( 28196072)
Interacting Genes		6 interacting genes: CACNA1A FLG PCSK5 PMCH RCN3 ZNF441	3 interacting genes: CSNK2A1 PCSK6 UCHL5
Entrez ID		5046	2312
HPRD ID		01329	15920
Ensembl ID		ENSG00000140479	ENSG00000143631
Uniprot IDs		A2RQD9 H7BXT3 P29122 Q59H04	P20930
PDB IDs			4PCW
Enriched GO Terms of Interacting Partners?
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