OVOL1 and LMNB2

Data Source:
BioGRID (two hybrid)

		OVOL1	LMNB2
Description		ovo like transcriptional repressor 1	lamin B2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Nuclear Inner Membrane Intermediate Filament Nuclear Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Molecular_function Protein Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Kidney Development Regulation Of Transcription By RNA Polymerase II Spermatogenesis Mesoderm Development Epidermal Cell Differentiation Skin Development Germline Cell Cycle Switching, Mitotic To Meiotic Cell Cycle Negative Regulation Of Meiotic Cell Cycle Phase Transition Negative Regulation Of Stem Cell Proliferation	Biological_process
Pathways
Drugs
Diseases
GWAS		Acne (severe) ( 24927181 30542056) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic sensitization ( 30013184) Apolipoprotein A1 levels ( 32203549) Asthma ( 31361310 30929738 32296059 31619474) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Atopic dermatitis ( 23042114 22197932 26482879) Atopic march ( 26542096) Blond vs. brown/black hair color ( 30531825) Blood protein levels ( 29875488) Breast cancer ( 23535729) Chronic kidney disease ( 20383146) DNA methylation (variation) ( 23725790) Eczema ( 31361310) Estimated glomerular filtration rate ( 31451708) High density lipoprotein cholesterol levels ( 31928498) Medication use (diuretics) ( 31015401) Rosacea symptom severity ( 29771307) Serum uric acid levels ( 30993211) Systemic lupus erythematosus ( 26502338 28714469) Systolic blood pressure ( 31928498) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Urate levels ( 23263486) Waist circumference ( 31928498)
Interacting Genes		3 interacting genes: FAM90A1 LMNB2 MAFF	30 interacting genes: AMOT AMOTL2 CA8 CCDC120 CCDC88B CDC37 EFHC2 FH GOLGA2 LMNA LMNB1 LZTS1 MFAP1 MID2 OVOL1 PIBF1 POU6F2 PPP1R13B PRKCD SVIL TFIP11 THAP1 TMPO TP53BP2 TRIM27 TSGA10IP USP2 WASHC3 ZC2HC1C ZFHX3
Entrez ID		5017	84823
HPRD ID		09080	01037
Ensembl ID		ENSG00000172818	ENSG00000176619
Uniprot IDs		G3V1B0 O14753	Q03252
PDB IDs			2LLL 5BNW
Enriched GO Terms of Interacting Partners?
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