ORC4 and ORC2

Data Source:
HPRD (in vivo, in vitro)

		ORC4	ORC2
Description		origin recognition complex subunit 4	origin recognition complex subunit 2
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Origin Recognition Complex Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Nucleolus Cytosol	Chromosome, Telomeric Region Heterochromatin Origin Recognition Complex Condensed Chromosome Inner Kinetochore Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Centrosome Membrane
	Molecular Function	Nucleotide Binding DNA Replication Origin Binding Protein Binding ATP Binding	DNA Replication Origin Binding Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication Initiation	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II DNA Replication DNA Replication Initiation
Pathways		E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex	E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex
Drugs
Diseases		Patella dysplasias, including: Small patella syndrome (SPS); Nail-patella syndrome; Ear-patella-short statute syndrome
GWAS		Estimated glomerular filtration rate ( 31152163 31015462 30604766) Loneliness (MTAG) ( 29970889) Serum uric acid levels ( 30993211) Urate levels ( 31578528)	Plasma parathyroid hormone levels ( 30134803) Triptolide cytotoxicity ( 26121980)
Interacting Genes		28 interacting genes: APP CCND1 CDKN2A CTBP1 FBXL5 FBXL8 FBXO25 FBXO6 H3-4 H4-16 KPNA1 MCM10 MCM2 MCM3 MCM4 MCM6 MCM7 MLH1 MTUS1 ORC1 ORC2 ORC3 ORC5 ORC6 RDH5 RPA2 RRM2B TCF4	28 interacting genes: CDC45 CDC5L CDC6 CDK2 CDT1 CTNNA3 DBF4 EP300 H3-4 H4-16 KAT7 MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 ORC1 ORC3 ORC4 ORC5 ORC6 RAD18 RIPPLY3 RPA1 RPA2 XRCC5
Entrez ID		5000	4999
HPRD ID		09118	03112
Ensembl ID		ENSG00000115947	ENSG00000115942
Uniprot IDs		A8K7H4 O43929 Q96B14	A0A024R411 Q13416
PDB IDs		5UJ7 5UJM 7JPO 7JPP 7JPQ 7JPR 7JPS	5C8H 5UJ8 5UJM 7JPO 7JPP 7JPQ 7JPR 7JPS
Enriched GO Terms of Interacting Partners?
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