OPRL1 and PNOC

Data Source:
BioGRID (pull down, pull down)
HPRD (in vitro, in vivo)

		OPRL1	PNOC
Description		opioid related nociceptin receptor 1	prepronociceptin
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cytoplasmic Vesicle Neuron Projection	Extracellular Region Plasma Membrane Dendrite Neuronal Cell Body Axon Terminus
	Molecular Function	Nociceptin Receptor Activity G Protein-coupled Receptor Activity Protein Binding Peptide Binding Neuropeptide Binding	Opioid Peptide Activity Neuropeptide Hormone Activity Opioid Receptor Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Sensory Perception Behavior Sensory Perception Of Pain Opioid Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway	Signal Transduction G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Chemical Synaptic Transmission Female Pregnancy Sensory Perception
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events	Peptide ligand-binding receptors G alpha (i) signalling events
Drugs		Buprenorphine Etorphine Epicept NP-1
Diseases
GWAS		Cerebrospinal AB1-42 levels in normal cognition ( 29274321) HDL cholesterol levels ( 32203549) LDL peak particle diameter (total fat intake interaction) ( 26112879) Lymphocyte counts ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic syndrome ( 31589552) Monocyte count ( 32888494) Triglyceride levels ( 32203549 32154731)	Body mass index ( 28892062) Metabolite levels ( 23823483)
Interacting Genes		10 interacting genes: CERS6 DNAJC30 GNA14 GPRASP1 HLA-C OPRM1 PLLP PNOC RGS19 SLC31A2	2 interacting genes: FBXO7 OPRL1
Entrez ID		4987	5368
HPRD ID		03971	03268
Ensembl ID		ENSG00000125510	ENSG00000168081
Uniprot IDs		A0A5F9ZI64 P41146 Q8IXB0	Q13519
PDB IDs		4EA3 5DHG 5DHH
Enriched GO Terms of Interacting Partners?
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