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OAZ1 and HTR2B
Data Source:
BioGRID
(two hybrid)
OAZ1
HTR2B
Description
ornithine decarboxylase antizyme 1
5-hydroxytryptamine receptor 2B
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Nucleoplasm
Cytoplasm
Plasma Membrane
Integral Component Of Plasma Membrane
Dendrite
Synapse
G Protein-coupled Serotonin Receptor Complex
Molecular Function
Protein Binding
Ornithine Decarboxylase Inhibitor Activity
Gq/11-coupled Serotonin Receptor Activity
G-protein Alpha-subunit Binding
G Protein-coupled Serotonin Receptor Activity
GTPase Activator Activity
Protein Binding
Neurotransmitter Receptor Activity
Serotonin Binding
Biological Process
Regulation Of Cellular Amino Acid Metabolic Process
Polyamine Biosynthetic Process
Negative Regulation Of Catalytic Activity
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Intracellular Protein Transport
Negative Regulation Of Polyamine Transmembrane Transport
Neural Crest Cell Migration
Positive Regulation Of Cytokine Production
Positive Regulation Of Endothelial Cell Proliferation
G Protein-coupled Receptor Internalization
Heart Morphogenesis
Cardiac Muscle Hypertrophy
Cellular Calcium Ion Homeostasis
G Protein-coupled Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
Activation Of Phospholipase C Activity
Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway
Phospholipase C-activating Serotonin Receptor Signaling Pathway
Chemical Synaptic Transmission
Behavior
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Autophagy
Positive Regulation Of Phosphatidylinositol Biosynthetic Process
Neural Crest Cell Differentiation
Phosphatidylinositol 3-kinase Signaling
Intestine Smooth Muscle Contraction
Phosphorylation
Calcium-mediated Signaling
CGMP-mediated Signaling
Vasoconstriction
Response To Drug
Negative Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of GTPase Activity
Embryonic Morphogenesis
Regulation Of Behavior
Positive Regulation Of Nitric-oxide Synthase Activity
Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Cell Division
Negative Regulation Of Cell Death
ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Protein Kinase C Signaling
Cellular Response To Temperature Stimulus
G Protein-coupled Serotonin Receptor Signaling Pathway
Pathways
Regulation of ornithine decarboxylase (ODC)
Serotonin receptors
G alpha (q) signalling events
Drugs
Ornithine
Methysergide
Cabergoline
Zolmitriptan
Dihydroergotamine
Methylergometrine
Chlorpromazine
Triflupromazine
Amoxapine
Fenfluramine
Lisuride
Ergotamine
Apomorphine
Paroxetine
Paroxetine
Minaprine
Cyclobenzaprine
Ergoloid mesylate
Tegaserod
Doxepin
Pergolide
Bromocriptine
Ketamine
Aripiprazole
Chlorprothixene
Clomipramine
Yohimbine
Midomafetamine
Lysergic acid diethylamide
OPC-28326
Epicept NP-1
PRX-08066
Cariprazine
Mianserin
Pizotifen
Asenapine
Ocaperidone
Esmirtazapine
Pipamperone
Setiptiline
Dihydroergocornine
Gilteritinib
Tiapride
Dihydroergocristine
Diseases
GWAS
Proportion of activated microglia (midfrontal cortex) (
30679421
)
Thiazide-induced adverse metabolic effects in hypertensive patients (
23400010
)
Interacting Genes
11 interacting genes:
AGTR1
ATXN1
EGFR
HTR2B
NLGN3
OAZ2
OAZ3
ODC1
PIAS4
PSMB4
SMAD1
27 interacting genes:
ABCA3
ATP1B1
BNIP3
BNIP3L
CBR1
CHPT1
G6PC3
GNA11
GNAQ
HAT1
HDGFL2
INSIG1
KIF19
LNX1
MATR3
METRN
NAT14
NIPA2
OAZ1
PLLP
PPP1R3F
RAE1
SLC31A2
SLC37A1
SLC44A2
SNTA1
TRAM1L1
Entrez ID
4946
3357
HPRD ID
03346
03077
Ensembl ID
ENSG00000104904
ENSG00000135914
Uniprot IDs
J3QQY4
P54368
P41595
PDB IDs
4ZGY
4ZGZ
5BWA
4IB4
4NC3
5TUD
5TVN
6DRX
6DRY
6DRZ
6DS0
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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