OAZ1 and GCH1

Data Source:
BioGRID (affinity chromatography technology)

		OAZ1	GCH1
Description		ornithine decarboxylase antizyme 1	GTP cyclohydrolase 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Vesicle Nuclear Membrane Protein-containing Complex Neuron Projection Terminus
	Molecular Function	Protein Binding Ornithine Decarboxylase Inhibitor Activity	GTPase Activity GTP Cyclohydrolase I Activity Calcium Ion Binding Protein Binding GTP Binding Zinc Ion Binding GTP-dependent Protein Binding Translation Initiation Factor Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Mitogen-activated Protein Kinase Binding
	Biological Process	Regulation Of Cellular Amino Acid Metabolic Process Polyamine Biosynthetic Process Negative Regulation Of Catalytic Activity Positive Regulation Of Protein Catabolic Process Positive Regulation Of Intracellular Protein Transport Negative Regulation Of Polyamine Transmembrane Transport	Tetrahydrobiopterin Biosynthetic Process Nitric Oxide Biosynthetic Process Regulation Of Blood Pressure Positive Regulation Of Heart Rate Regulation Of Lung Blood Pressure Response To Lipopolysaccharide Response To Interferon-gamma Response To Tumor Necrosis Factor 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Vasodilation Dopamine Biosynthetic Process Pteridine-containing Compound Biosynthetic Process Negative Regulation Of Blood Pressure Tetrahydrofolate Biosynthetic Process Response To Pain Neuromuscular Process Controlling Posture Positive Regulation Of Nitric-oxide Synthase Activity Protein-containing Complex Assembly Regulation Of Removal Of Superoxide Radicals
Pathways		Regulation of ornithine decarboxylase (ODC)	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Drugs		Ornithine	Guanine
Diseases			Primary torsion dystonia (PTD) Phenylketonuria (PKU); Hyperphenylalaninemia, BH4-deficient
GWAS			Chronotype ( 30696823) Mercury levels ( 26025379) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Parkinson's disease ( 25064009 32201043 27182965 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Rheumatoid arthritis ( 22446963)
Interacting Genes		11 interacting genes: AGTR1 ATXN1 EGFR HTR2B NLGN3 OAZ2 OAZ3 ODC1 PIAS4 PSMB4 SMAD1	15 interacting genes: AHSA1 ATP1B1 CDC37 CNRIP1 GCHFR GIT2 HSPA8 RAB26 RLF RPH3A SH3GL2 SP3 TNPO2 TNPO3 YWHAZ
Entrez ID		4946	2643
HPRD ID		03346	02573
Ensembl ID		ENSG00000104904	ENSG00000131979
Uniprot IDs		J3QQY4 P54368	A0A024R642 P30793 Q8IZH9
PDB IDs		4ZGY 4ZGZ 5BWA	1FB1
Enriched GO Terms of Interacting Partners?
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