CHAC2 and XPO1

Data Source:
HPRD (in vivo)

		CHAC2	XPO1
Description		ChaC glutathione specific gamma-glutamylcyclotransferase 2	exportin 1
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GO Annotations	Cellular Component	Cellular_component Cytoplasm Cytosol	Kinetochore Nucleus Nuclear Envelope Annulate Lamellae Nucleoplasm Nucleolus Cytoplasm Cytosol Cajal Body Membrane Nuclear Membrane Protein-containing Complex Intracellular Membrane-bounded Organelle Host Cell Ribonucleoprotein Complex
	Molecular Function	Molecular_function Gamma-glutamylcyclotransferase Activity Glutathione Specific Gamma-glutamylcyclotransferase Activity	RNA Binding Nuclear Export Signal Receptor Activity Protein Binding
	Biological Process	Glutathione Biosynthetic Process Glutathione Catabolic Process Biological_process	Ribosomal Subunit Export From Nucleus Ribosomal Large Subunit Export From Nucleus Ribosomal Small Subunit Export From Nucleus Protein Export From Nucleus Nucleocytoplasmic Transport Viral Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Ribosome Biogenesis Regulation Of MRNA Stability MRNA Transport Intracellular Transport Of Virus
Pathways		Glutathione synthesis and recycling	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Rev-mediated nuclear export of HIV RNA NEP/NS2 Interacts with the Cellular Export Machinery Downregulation of TGF-beta receptor signaling Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Deactivation of the beta-catenin transactivating complex HuR (ELAVL1) binds and stabilizes mRNA RHO GTPases Activate Formins MAPK6/MAPK4 signaling Mitotic Prometaphase Cyclin A/B1/B2 associated events during G2/M transition Estrogen-dependent nuclear events downstream of ESR-membrane signaling EML4 and NUDC in mitotic spindle formation
Drugs			Selinexor
Diseases
GWAS		Nicotine dependence symptom count ( 25555482) Refractive error ( 32231278)	Atrial fibrillation ( 29892015) Eosinophil counts ( 32888494 27863252) Erectile dysfunction ( 30583798) Mean reticulocyte volume ( 32888494) Neutrophil count ( 32888494) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 28714469) Urinary sodium excretion ( 31409800) White blood cell count ( 32888494)
Interacting Genes		1 interacting genes: APP	80 interacting genes: ABL1 ADAR AGFG1 AHR ANP32A ANP32B APC ATF2 BECN1 BIRC5 BRCA2 CCND1 CDC25A CDC42 CDCA4 CDKN1B CHEK1 CHORDC1 CIITA CRK DDX3X DESI1 DR1 E2F4 E2F5 EIF5A ERF FBXO7 FOXO4 HDAC3 HNF4A HSPA9 HSPB1 IRF5 KIF17 LINC01554 MAPK6 NF2 NMD3 NPM1 NUCB1 NUCB2 NUP153 NUP214 NUP50 NUP62 NXF3 NXT1 ORC1 PHAX PHB PKIA RAD51 RAN RANBP2 RANBP3 RCC1 RCN2 RGS14 RIC8A RPS6KB1 SERPINB1 SERTAD2 SIRT2 SMAD1 SMARCB1 SMURF1 SMURF2 SNUPN SOX2 STAT1 STRADA SUMO1 SUMO2 TERF2IP TERT TOP2A TOP2B TP53 TP73
Entrez ID		494143	7514
HPRD ID		17418	03975
Ensembl ID		ENSG00000143942	ENSG00000082898
Uniprot IDs		Q8WUX2	B3KWD0 O14980
PDB IDs		6K95 6KY0 6KY1	1W9C 2L1L 3GB8 4BSM 4BSN 5DIS 6TVO
Enriched GO Terms of Interacting Partners?
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