NUP98 and HBE1

Data Source:
BioGRID (x-ray crystallography)

		NUP98	HBE1
Description		nucleoporin 98 and 96 precursor	hemoglobin subunit epsilon 1
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GO Annotations	Cellular Component	Kinetochore Nuclear Envelope Nuclear Pore Nucleoplasm Cytosol Nuclear Body Nuclear Pore Outer Ring Nuclear Membrane Nuclear Periphery Nuclear Inclusion Body Intracellular Membrane-bounded Organelle Host Cell Nuclear Pore Nuclear Basket Ribonucleoprotein Complex	Cytosol Hemoglobin Complex Haptoglobin-hemoglobin Complex Blood Microparticle
	Molecular Function	Transcription Coactivator Activity MRNA Binding Transporter Activity Protein Binding Nuclear Localization Sequence Binding Serine-type Peptidase Activity Structural Constituent Of Nuclear Pore Promoter-specific Chromatin Binding	Peroxidase Activity Oxygen Carrier Activity Protein Binding Oxygen Binding Heme Binding Haptoglobin Binding Hemoglobin Alpha Binding Organic Acid Binding Protein-containing Complex Binding Metal Ion Binding
	Biological Process	Regulation Of Glycolytic Process MRNA Export From Nucleus TRNA Export From Nucleus Proteolysis Protein Import Into Nucleus Nucleocytoplasmic Transport Nuclear Pore Organization Viral Process Protein Sumoylation Viral Transcription Positive Regulation Of Transcription, DNA-templated Positive Regulation Of MRNA Splicing, Via Spliceosome Nuclear Pore Complex Assembly Regulation Of Gene Silencing By MiRNA Intracellular Transport Of Virus Regulation Of Cellular Response To Heat	Blood Coagulation Response To Organic Cyclic Compound Oxygen Transport Hydrogen Peroxide Catabolic Process Cellular Oxidant Detoxification
Pathways			Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Malaria ( 31844061) Metabolite levels (Dihydroxy docosatrienoic acid) ( 23934736)	Beta thalassemia/hemoglobin E disease ( 20183929) Hematology traits ( 23263863) Hemoglobin ( 28548082) Hemoglobin levels ( 26366553) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Logical memory (delayed recall) in normal cognition ( 29274321) Logical memory (immediate recall) in normal cognition ( 29274321) Malaria ( 31844061) Mean corpuscular hemoglobin concentration ( 23263863 28453575) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 32888494 27863252) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		19 interacting genes: APC CREBBP CSNK2A1 EP300 HDAC1 IPO5 KPNB1 NFX1 NUP133 NUP155 NUP62 NUP88 NXF1 RAE1 RCC1 SEC13 TNPO1 TNPO2 TPR	4 interacting genes: HBA1 HBA2 HBQ1 HBZ
Entrez ID		4928	3046
HPRD ID		03012	00788
Ensembl ID		ENSG00000110713	ENSG00000213931
Uniprot IDs		P52948	D9YZU7 P02100
PDB IDs		1KO6 2Q5X 2Q5Y 3MMY 4OWR 5A9Q 6BZM	1A9W
Enriched GO Terms of Interacting Partners?
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