NTF4 and CLIC1

Data Source:
BioGRID (two hybrid)

		NTF4	CLIC1
Description		neurotrophin 4	chloride intracellular channel 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Synaptic Vesicle Axon Dendrite	Extracellular Space Nucleus Nuclear Envelope Cytoplasm Mitochondrion Plasma Membrane Brush Border Membrane Nuclear Membrane Vesicle Chloride Channel Complex Perinuclear Region Of Cytoplasm Extracellular Exosome Blood Microparticle
	Molecular Function	Nerve Growth Factor Receptor Binding Protein Binding Growth Factor Activity	Voltage-gated Ion Channel Activity Chloride Channel Activity Protein Binding Cadherin Binding
	Biological Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Activation Of Phospholipase C Activity Ganglion Mother Cell Fate Determination Peripheral Nervous System Development Memory Long-term Memory Sensory Organ Boundary Specification Adult Locomotory Behavior Epidermis Development Nerve Development Positive Regulation Of Peptidyl-serine Phosphorylation Nerve Growth Factor Signaling Pathway Mechanoreceptor Differentiation Negative Regulation Of Neuron Apoptotic Process Regulation Of Neuron Differentiation Neurotrophin TRK Receptor Signaling Pathway Neuron Projection Morphogenesis Modulation Of Chemical Synaptic Transmission Innervation Taste Bud Development	Glutathione Metabolic Process Chloride Transport Signal Transduction Regulation Of Ion Transmembrane Transport Positive Regulation Of Osteoblast Differentiation Regulation Of Cell Cycle Regulation Of Mitochondrial Membrane Potential Platelet Aggregation Chloride Transmembrane Transport
Pathways		NTF4 activates NTRK2 (TRKB) signaling Activated NTRK2 signals through RAS Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through PI3K Activated NTRK2 signals through FRS2 and FRS3 Activated NTRK2 signals through FRS2 and FRS3
Drugs			Copper Artenimol
Diseases		Primary open angle glaucoma
GWAS		Asparaginase-induced acute pancreatitis in acute lymphoblastic leukemia (onset time) ( 27114598)	Adult body size ( 32376654) Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Inflammatory bowel disease ( 28067908) Mean platelet volume ( 27863252) Ulcerative colitis ( 28067908)
Interacting Genes		8 interacting genes: ADAMTSL4 BDNF CLIC1 CRX GLRX3 LRP1 NGFR NTRK2	22 interacting genes: AKAP9 ALOX5AP ATP5PB ATP6V0A1 ATP6V0C CPT1A IKBKG LSM1 MEOX2 MYOC NHSL2 NTF4 NUP62 PRDX4 PSMD10 RPLP1 SUMO4 THRA TPRN TRAPPC2 ZNF184 ZNF302
Entrez ID		4909	1192
HPRD ID		01220	04188
Ensembl ID		ENSG00000225950	ENSG00000213719
Uniprot IDs		A0A024QZE4 P34130	O00299 Q53FB0 Q5SRT3
PDB IDs		1B8M 1B98 1HCF	1K0M 1K0N 1K0O 1RK4 3O3T 3P8W 3P90 3QR6 3SWL 3TGZ 3UVH 4IQA 4JZQ 4K0G 4K0N
Enriched GO Terms of Interacting Partners?
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