ATP2A1 and SLN

Data Source:
HPRD (in vivo)

		ATP2A1	SLN
Description		ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1	sarcolipin
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Membrane Integral Component Of Membrane Sarcoplasmic Reticulum Platelet Dense Tubular Network Membrane Sarcoplasmic Reticulum Membrane Calcium Channel Complex	Integral Component Of Membrane Sarcoplasmic Reticulum Sarcoplasmic Reticulum Membrane
	Molecular Function	Calcium Transmembrane Transporter Activity, Phosphorylative Mechanism Calcium Ion Binding Protein Binding ATP Binding Proton-exporting ATPase Activity, Phosphorylative Mechanism ATPase Activity Calcium-dependent ATPase Activity Protein Homodimerization Activity	Enzyme Inhibitor Activity Protein Binding ATPase Binding
	Biological Process	Calcium Ion Transport Cellular Calcium Ion Homeostasis Apoptotic Mitochondrial Changes Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Positive Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Ion Transmembrane Transport Response To Endoplasmic Reticulum Stress Positive Regulation Of Mitochondrial Calcium Ion Concentration Maintenance Of Mitochondrion Location Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Calcium Ion Import Calcium Ion Transmembrane Transport Relaxation Of Skeletal Muscle Positive Regulation Of Cardiac Muscle Cell Contraction Positive Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Positive Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Proton Transmembrane Transport Regulation Of Cardiac Conduction Calcium Ion Import Into Sarcoplasmic Reticulum	Calcium Ion Transport Negative Regulation Of Catalytic Activity Negative Regulation Of Protein-containing Complex Disassembly Regulation Of Calcium Ion Transport Sarcoplasmic Reticulum Calcium Ion Transport Negative Regulation Of Calcium Ion Import Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Relaxation Of Muscle Negative Regulation Of Calcium Ion Binding Positive Regulation Of Protein Depolymerization Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity
Pathways		Pre-NOTCH Processing in Golgi Reduction of cytosolic Ca++ levels Ion homeostasis Ion transport by P-type ATPases	Ion homeostasis Ion transport by P-type ATPases
Drugs		Enflurane Desflurane Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate Tetrafluoroaluminate Ion 2,5-di-tert-butylhydroquinone (6AR,11AS,11BR)-10-ACETYL-9-HYDROXY-7,7-DIMETHYL-2,6,6A,7,11A,11B-HEXAHYDRO-11H-PYRROLO[1',2':2,3]ISOINDOLO[4,5,6-CD]INDOL-11-ONE
Diseases		Brody myopathy
GWAS		BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 19079260 26961502 28892062 25673413) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Brain morphology (MOSTest) ( 32665545) Cannabis use ( 30150663) Crohn's disease ( 28067908) Extremely high intelligence ( 29520040) Hip circumference ( 31453325 25673412) Hip circumference variance ( 31453325) Inflammatory bowel disease ( 28067908) Intelligence ( 28530673) Intelligence (MTAG) ( 29326435) Lamb consumption ( 32066663) Type 2 diabetes ( 30297969) Waist circumference ( 31453325) Waist circumference variance ( 31453325) Weight ( 19079260)
Interacting Genes		8 interacting genes: APPL1 CCR8 IRS1 IRS2 PLN RNF167 SLN TULP3	7 interacting genes: ATP2A1 KASH5 LMNA PLN PTPN11 SYNE4 TMEM79
Entrez ID		487	6588
HPRD ID		00157	03729
Ensembl ID		ENSG00000196296	ENSG00000170290
Uniprot IDs		O14983 Q7Z675	A0A158RFT9 O00631
PDB IDs			1JDM
Enriched GO Terms of Interacting Partners?
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