PNP and TFAM

Data Source:
HPRD (in vitro)

		PNP	TFAM
Description		purine nucleoside phosphorylase	transcription factor A, mitochondrial
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GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Cytosol Cytoskeleton Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Nucleus Mitochondrion Mitochondrial Matrix Cytosol Protein-containing Complex Mitochondrial Nucleoid
	Molecular Function	Nucleoside Binding Purine Nucleobase Binding Purine-nucleoside Phosphorylase Activity Protein Binding Phosphate Ion Binding Identical Protein Binding	Transcription Regulatory Region Sequence-specific DNA Binding Mitochondrial Promoter Sequence-specific DNA Binding Transcription Coactivator Binding Chromatin Binding DNA-binding Transcription Factor Activity RNA Binding Protein Binding DNA Binding, Bending Heat Shock Protein Binding Mitochondrial Transcription Factor Activity Sequence-specific DNA Binding
	Biological Process	Nucleobase-containing Compound Metabolic Process Inosine Catabolic Process Purine Nucleotide Catabolic Process Nicotinamide Riboside Catabolic Process Immune Response Nucleotide Biosynthetic Process Interleukin-2 Production Urate Biosynthetic Process Positive Regulation Of T Cell Proliferation Response To Drug Purine-containing Compound Salvage Neutrophil Degranulation Positive Regulation Of Alpha-beta T Cell Differentiation	Mitochondrial Transcription Transcription Initiation From Mitochondrial Promoter Mitochondrion Organization Mitochondrial Respiratory Chain Complex Assembly Positive Regulation Of Transcription, DNA-templated
Pathways		Neutrophil degranulation Purine salvage Purine catabolism	Mitochondrial transcription initiation Transcriptional activation of mitochondrial biogenesis Transcriptional activation of mitochondrial biogenesis
Drugs		Cladribine Didanosine 8-azaguanine 2,6-Diamino-(S)-9-[2-(Phosphonomethoxy)Propyl]Purine Immucillin-G Guanine 2-Amino-7-[2-(2-Hydroxy-1-Hydroxymethyl-Ethylamino)-Ethyl]-1,7-Dihydro-Purin-6-One Peldesine 9-deazainosine Guanosine Ribose-1-Phosphate (3R,4R)-3-Hydroxy-4-(hydroxymethyl)-1-[(4-oxo-4,4a,5,7a-tetrahydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]pyrrolidinium 3'-deoxyguanosine (2S,3R,4S,5S)-3,4-Dihydroxy-2-[(methylsulfanyl)methyl]-5-(4-oxo-4,5-dihydro-1H-pyrrolo[3,2-d]pyrimidin-7-yl)pyrrolidinium Hypoxanthine 9-(5,5-Difluoro-5-Phosphonopentyl)Guanine Inosine 9-DEAZAINOSINE-2',3'-O-ETHYLIDENEPHOSPHONATE GUANOSINE-2',3'-O-ETHYLIDENEPHOSPHONATE GUANOSINE-2',3'-O-METHYLIDENEPHOSPHONATE Forodesine
Diseases		Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS		Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Blood protein levels ( 30072576) HDL cholesterol levels ( 32203549) Interferon alpha levels in systemic lupus erythematosus ( 25338677) Menopause (age at onset) ( 26414677)	Blood urea nitrogen levels ( 29403010) Height ( 23456168) Metabolite levels ( 23823483) Midgestational circulating levels of PCBs ( 28235828) Refractive error ( 32231278)
Interacting Genes		11 interacting genes: APLP1 CCDC90B LRIF1 NCALD NOS1AP RBM48 TFAM TFB2M TP53 UCHL5 ZHX1	10 interacting genes: AGTRAP ARL6IP1 COL8A2 MGST3 PNP STATH TECR TFB1M TFB2M TSPAN1
Entrez ID		4860	7019
HPRD ID		01247	02702
Ensembl ID		ENSG00000198805	ENSG00000108064
Uniprot IDs		P00491 V9HWH6	E5KSU5 Q00059
PDB IDs		1M73 1PF7 1PWY 1RCT 1RFG 1RR6 1RSZ 1RT9 1ULA 1ULB 1V2H 1V3Q 1V41 1V45 1YRY 2A0W 2A0X 2A0Y 2OC4 2OC9 2ON6 2Q7O 3BGS 3D1V 3GB9 3GGS 3INY 3K8O 3K8Q 3PHB 4EAR 4EB8 4ECE 4GKA 5ETJ 5UGF	3FGH 3TMM 3TQ6 4NNU 4NOD 6ERP 6ERQ 6HB4 6HC3
Enriched GO Terms of Interacting Partners?
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