NOTCH4 and SLC27A4

Data Source:
BioGRID (affinity chromatography technology)

		NOTCH4	SLC27A4
Description		notch receptor 4	solute carrier family 27 member 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Nucleus Nucleoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell Surface	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Microvillus Membrane Integral Component Of Membrane Brush Border Membrane
	Molecular Function	Notch Binding Calcium Ion Binding Protein Binding Signaling Receptor Activity	Nucleotide Binding Long-chain Fatty Acid-CoA Ligase Activity Long-chain Fatty Acid Transporter Activity Very Long-chain Fatty Acid-CoA Ligase Activity Arachidonate-CoA Ligase Activity Palmitoyl-CoA Ligase Activity Oleoyl-CoA Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Branching Involved In Blood Vessel Morphogenesis Cell Fate Determination Morphogenesis Of A Branching Structure Epithelial To Mesenchymal Transition Endothelial Cell Morphogenesis Vasculature Development Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription Of Notch Receptor Target Hemopoiesis Cell Differentiation Mammary Gland Development MiRNA Mediated Inhibition Of Translation Wound Healing Negative Regulation Of Cell Differentiation Negative Regulation Of Endothelial Cell Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin	Medium-chain Fatty Acid Transport Long-chain Fatty Acid Metabolic Process Fatty Acid Metabolic Process Response To Nutrient Fatty Acid Transport Long-chain Fatty Acid Transport Very Long-chain Fatty Acid Catabolic Process Positive Regulation Of Apoptotic Process Skin Development Glucose Import In Response To Insulin Stimulus Long-chain Fatty Acid Import Into Cell Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of All-trans-retinyl-ester Hydrolase, 11-cis Retinol Forming Activity Activation Of GTPase Activity Transport Across Blood-brain Barrier Lipid Transport Across Blood-brain Barrier
Pathways		Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Transcription and Translation Pre-NOTCH Processing in Golgi Pre-NOTCH Processing in Golgi Notch-HLH transcription pathway Defective LFNG causes SCDO3 NOTCH4 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription NOTCH4 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Negative regulation of NOTCH4 signaling Negative regulation of NOTCH4 signaling	Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS) Transport of fatty acids
Drugs
Diseases			Ichthyosis prematurity syndrome
GWAS		Advanced glycation end-product levels ( 26083729) Age-related macular degeneration ( 22694956) Aspartate aminotransferase levels ( 29403010) Asthma ( 21804548 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Blood protein levels ( 28240269) Blood protein levels in cardiovascular risk ( 28369058) Chronic hepatitis B infection ( 25802187) Circulating myeloperoxidase levels (serum) ( 23620142) Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 26876947) Colorectal cancer ( 30529582) Crohn's disease ( 23266558) Epstein-Barr virus immune response (EBNA-1) ( 23326239) Food antigen IgG levels ( 24962563) Hematocrit ( 32888494) Hemoglobin ( 32888494) High light scatter reticulocyte count ( 32888494) HIV-1 control ( 20041166) Inflammatory bowel disease ( 28067908) Iron status biomarkers (iron levels) ( 28334935) Joint mobility (Beighton score) ( 27182965) Longevity ( 30294719) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Lupus nephritis in systemic lupus erythematosus ( 24925725) Migraine ( 27322543) Mixed cryoglobulinemia vasculitis in chronic hepatitis C infection ( 25030430) Obesity-related traits ( 23251661) Objective response to lithium treatment in bipolar disorder ( 26503763) Prostate cancer ( 23535732) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 27863252) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Schizophrenia ( 19571808 30285260 23894747) Squamous cell lung carcinoma ( 28604730) Systemic lupus erythematosus ( 21408207) Systemic sclerosis ( 21779181) Takayasu arteritis ( 25604533) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Ulcerative colitis ( 24837172 28067908) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 28448500)	Body mass index ( 26426971)
Interacting Genes		13 interacting genes: DLL4 EGFL7 ELOC FBXW7 MAML1 MAML2 MAML3 PSEN1 PSEN2 RBPJ SMAD2 SMAD3 SMAD4	2 interacting genes: EPS8 TENT5B
Entrez ID		4855	10999
HPRD ID		01290	09172
Ensembl ID		ENSG00000204301	ENSG00000167114
Uniprot IDs		A0A1U9X983 Q99466	A0A024R8D2 Q6P1M0
PDB IDs
Enriched GO Terms of Interacting Partners?
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