NKX3-1 and STMN3

Data Source:
BioGRID (two hybrid)

		NKX3-1	STMN3
Description		NK3 homeobox 1	stathmin 3
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol Site Of DNA Damage	Cytoplasm Golgi Apparatus Cytosol Growth Cone Neuron Projection
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Transcription Factor Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Estrogen Receptor Activity Estrogen Receptor Binding Histone Deacetylase Binding Sequence-specific DNA Binding Protein Self-association MADS Box Domain Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Tubulin Binding Protein Domain Specific Binding
	Biological Process	Metanephros Development Somitogenesis Positive Regulation Of Protein Phosphorylation Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Multicellular Organism Development Salivary Gland Development Heart Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Male Gonad Development Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Cell Death Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Differentiation Androgen Receptor Signaling Pathway Regulation Of Protein Localization Response To Testosterone Cellular Response To Drug Dorsal Aorta Development Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Kinase B Signaling Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Branching Morphogenesis Of An Epithelial Tube Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Cell Division Pharyngeal System Development Branching Involved In Prostate Gland Morphogenesis Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Steroid Hormone Stimulus Cellular Response To Hypoxia Mitotic Cell Cycle Arrest Negative Regulation Of Estrogen Receptor Binding Positive Regulation Of Androgen Secretion Positive Regulation Of Response To DNA Damage Stimulus Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Microtubule Depolymerization Nervous System Development Regulation Of Microtubule Polymerization Or Depolymerization Cytoplasmic Microtubule Organization Neuron Projection Development Negative Regulation Of Rac Protein Signal Transduction Regulation Of GTPase Activity Regulation Of Cytoskeleton Organization
Pathways
Drugs
Diseases		Prostate cancer
GWAS		Birth weight ( 31043758) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular hemoglobin concentration ( 29403010) Prostate cancer ( 32986714 26443449) Prostate-specific antigen levels ( 28139693) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma or allergic disease (pleiotropy) ( 29785011) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Leukocyte telomere length ( 32109421) Mean corpuscular hemoglobin ( 32888494) Prostate cancer ( 23535732) Refractive error ( 32231278) Ulcerative colitis ( 28067908 21297633)
Interacting Genes		37 interacting genes: AEN CCT7 CD200R1L CENPX CHPF CKAP4 FEM1B HIPK2 HMG20B HNRNPA0 HSP90B1 LMCD1 MAN2B1 MNAT1 MT-ND4 PEBP1 PTMS RABL6 RARG RHOXF2 RNF4 RPL37A RPSA SLC22A18 SP1 SP2 SP3 SP4 SP5 SPDEF SRF STMN3 TEX264 TOPORS TPT1 WDR77 ZNF417	27 interacting genes: ANKRD11 C1orf109 CARD9 CLIC3 EXOC8 GLP1R GPANK1 HGS KAT5 KIFC3 KRT34 LTB4R2 MIPOL1 MKRN3 MNS1 NKX3-1 P4HA3 PLEKHA7 POLR1C SMARCD1 SPCS2 TBC1D21 TRIM69 TRPC5 TXLNB UBQLN1 ZNF76
Entrez ID		4824	50861
HPRD ID		03620	16324
Ensembl ID		ENSG00000167034	ENSG00000197457
Uniprot IDs		Q99801	Q9NZ72
PDB IDs		2L9R
Enriched GO Terms of Interacting Partners?
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