NKX2-2 and RASSF2

Data Source:
HPRD (in vitro)

		NKX2-2	RASSF2
Description		NK2 homeobox 2	Ras association domain family member 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Kinetochore Condensed Chromosome Kinetochore Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Protein-containing Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Transcription Factor Binding	Protein Kinase Activity Protein Binding
	Biological Process	Type B Pancreatic Cell Development Pancreatic A Cell Fate Commitment Type B Pancreatic Cell Fate Commitment Pancreatic PP Cell Fate Commitment Regulation Of Transcription By RNA Polymerase II Smoothened Signaling Pathway Brain Development Response To Glucose Oligodendrocyte Development Spinal Cord Motor Neuron Differentiation Spinal Cord Oligodendrocyte Cell Fate Specification Optic Nerve Development Cell Differentiation Endocrine Pancreas Development Response To Progesterone Negative Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Development Neuron Fate Specification Astrocyte Differentiation Positive Regulation Of Oligodendrocyte Differentiation Ventral Spinal Cord Interneuron Fate Determination	Skeletal System Development Ossification Protein Phosphorylation Cell Cycle Signal Transduction Positive Regulation Of Protein Autophosphorylation Negative Regulation Of Peptidyl-serine Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway Via I-kappaB Kinase/NF-kappaB Cascade Positive Regulation Of Apoptotic Process Regulation Of Osteoblast Differentiation Regulation Of Osteoclast Differentiation Positive Regulation Of Protein Kinase Activity Positive Regulation Of JNK Cascade Bone Remodeling Homeostasis Of Number Of Cells Protein Stabilization Regulation Of NIK/NF-kappaB Signaling Negative Regulation Of NIK/NF-kappaB Signaling
Pathways		Regulation of gene expression in beta cells Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells
Drugs
Diseases
GWAS		Autism spectrum disorder ( 30804558) Chronotype ( 30696823) Ewing sarcoma ( 30093639) Hyperglycemia in higher physical activity ( 30327367) Lupus nephritis in systemic lupus erythematosus ( 24925725) Refractive error ( 32231278)	Refractive error ( 32231278) Systemic lupus erythematosus ( 24871463)
Interacting Genes		1 interacting genes: OLIG2	9 interacting genes: HRAS KDM1A KRAS PRMT3 PRMT6 RASSF5 S100Z STK3 SUV39H1
Entrez ID		4821	9770
HPRD ID		05213	15218
Ensembl ID		ENSG00000125820	ENSG00000101265
Uniprot IDs		O95096	P50749
PDB IDs
Enriched GO Terms of Interacting Partners?
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