NKX2-2 and CDK5RAP1

Data Source:
BioGRID (affinity chromatography technology)

		NKX2-2	CDK5RAP1
Description		NK2 homeobox 2	CDK5 regulatory subunit associated protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Cellular_component Mitochondrion Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Transcription Factor Binding	Protein Kinase Binding N6-isopentenyladenosine Methylthiotransferase Activity Protein-containing Complex Binding Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Type B Pancreatic Cell Development Pancreatic A Cell Fate Commitment Type B Pancreatic Cell Fate Commitment Pancreatic PP Cell Fate Commitment Regulation Of Transcription By RNA Polymerase II Smoothened Signaling Pathway Brain Development Response To Glucose Oligodendrocyte Development Spinal Cord Motor Neuron Differentiation Spinal Cord Oligodendrocyte Cell Fate Specification Optic Nerve Development Cell Differentiation Endocrine Pancreas Development Response To Progesterone Negative Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Development Neuron Fate Specification Astrocyte Differentiation Positive Regulation Of Oligodendrocyte Differentiation Ventral Spinal Cord Interneuron Fate Determination	Brain Development TRNA Methylthiolation Regulation Of Neuron Differentiation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Translational Fidelity Positive Regulation Of Mitochondrial Translation Mitochondrial TRNA Modification
Pathways		Regulation of gene expression in beta cells Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells
Drugs
Diseases
GWAS		Autism spectrum disorder ( 30804558) Chronotype ( 30696823) Ewing sarcoma ( 30093639) Hyperglycemia in higher physical activity ( 30327367) Lupus nephritis in systemic lupus erythematosus ( 24925725) Refractive error ( 32231278)	Diastolic blood pressure ( 30224653) Hip circumference adjusted for BMI ( 25673412) Mean corpuscular volume ( 32888494)
Interacting Genes		1 interacting genes: OLIG2	4 interacting genes: CDK5 CDK5R1 EXOSC3 EXOSC5
Entrez ID		4821	51654
HPRD ID		05213	12189
Ensembl ID		ENSG00000125820	ENSG00000101391
Uniprot IDs		O95096	A0A0S2Z592 A0A0S2Z5J9 Q53H36 Q96SZ6
PDB IDs
Enriched GO Terms of Interacting Partners?
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