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NFYB and DUSP6
Data Source:
BioGRID
(affinity chromatography technology)
NFYB
DUSP6
Description
nuclear transcription factor Y subunit beta
dual specificity phosphatase 6
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
CCAAT-binding Factor Complex
Protein-DNA Complex
RNA Polymerase II Transcription Regulator Complex
Nucleoplasm
Cytoplasm
Cytosol
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Protein Heterodimerization Activity
Repressing Transcription Factor Binding
Phosphoprotein Phosphatase Activity
Protein Tyrosine Phosphatase Activity
Protein Binding
Protein Tyrosine/threonine Phosphatase Activity
MAP Kinase Tyrosine/serine/threonine Phosphatase Activity
Mitogen-activated Protein Kinase Binding
Protein Serine Phosphatase Activity
Protein Threonine Phosphatase Activity
Biological Process
Regulation Of Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
Regulation Of Cholesterol Biosynthetic Process
Positive Regulation Of Transcription By RNA Polymerase II
MAPK Cascade
Activation Of MAPK Activity
Inactivation Of MAPK Activity
Protein Dephosphorylation
Response To Organic Cyclic Compound
Cell Differentiation
Peptidyl-tyrosine Dephosphorylation
Peptidyl-threonine Dephosphorylation
Response To Drug
Positive Regulation Of Apoptotic Process
Response To Nitrosative Stress
Regulation Of Heart Growth
Negative Regulation Of ERK1 And ERK2 Cascade
Response To Growth Factor
Pathways
PPARA activates gene expression
Activation of gene expression by SREBF (SREBP)
Activation of gene expression by SREBF (SREBP)
ATF4 activates genes in response to endoplasmic reticulum stress
ATF6 (ATF6-alpha) activates chaperone genes
ATF6 (ATF6-alpha) activates chaperone genes
FOXO-mediated transcription of cell death genes
RAF-independent MAPK1/3 activation
ERKs are inactivated
Negative regulation of MAPK pathway
Signaling by MAPK mutants
Drugs
Diseases
GWAS
Toenail selenium levels (
25343990
)
Attention deficit hyperactivity disorder (
29325848
30478444
)
Night sleep phenotypes (
27126917
)
Interacting Genes
26 interacting genes:
AGTRAP
C1QBP
CEBPZ
CIITA
CNTN2
DRAP1
ELF1
EP300
GRB2
MAOB
MEOX2
MYC
NFYA
NFYC
POLE4
POU3F2
SMYD3
SP1
TAF11
TAF12
TAF6
TBP
TP53
TP73
YBX1
YBX3
12 interacting genes:
AATK
ERBB4
LMTK2
LTK
MAPK1
MAPK3
MDFI
ROR2
SRPK1
TEX11
TXK
ZNF212
Entrez ID
4801
1848
HPRD ID
01794
04124
Ensembl ID
ENSG00000120837
ENSG00000139318
Uniprot IDs
A0A024RBG7
F8VSL3
P25208
A0A024RBC1
Q16828
Q53GP9
PDB IDs
1N1J
4AWL
4CSR
6QMP
6QMQ
6QMS
1HZM
1MKP
Enriched GO Terms of Interacting Partners
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