NFATC4 and NLGN3

Data Source:
BioGRID (two hybrid)

		NFATC4	NLGN3
Description		nuclear factor of activated T cells 4	neuroligin 3
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex Cytosol Nuclear Speck	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Endocytic Vesicle Synapse Excitatory Synapse Spanning Component Of Membrane Presynapse Symmetric, GABA-ergic, Inhibitory Synapse Asymmetric, Glutamatergic, Excitatory Synapse Integral Component Of Postsynaptic Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Transcription Factor Binding Peroxisome Proliferator Activated Receptor Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Signaling Receptor Activity Neurexin Family Protein Binding Cell Adhesion Molecule Binding Scaffold Protein Binding
	Biological Process	Branching Involved In Blood Vessel Morphogenesis Cytokine Production Regulation Of Transcription By RNA Polymerase II Inflammatory Response Heart Development Long-term Memory Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Wnt Signaling Pathway Brain-derived Neurotrophic Factor Receptor Signaling Pathway Negative Regulation Of Protein Binding Positive Regulation Of Tumor Necrosis Factor Production Calcineurin-NFAT Signaling Cascade Cellular Response To UV Negative Regulation Of Chromatin Binding Negative Regulation Of Neuron Apoptotic Process Cellular Respiration Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Dendrite Morphogenesis Smooth Muscle Cell Differentiation Muscle Cell Development Long-term Synaptic Potentiation Cellular Response To Lithium Ion Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II Cellular Response To Ionomycin Negative Regulation Of Synapse Maturation Positive Regulation Of Apoptotic Signaling Pathway	Regulation Of Respiratory Gaseous Exchange By Nervous System Process Receptor-mediated Endocytosis Neuron Cell-cell Adhesion Chemical Synaptic Transmission Synapse Assembly Learning Adult Behavior Social Behavior Synaptic Vesicle Endocytosis Axon Extension Modulation Of Chemical Synaptic Transmission Synapse Organization Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Rhythmic Synaptic Transmission Inhibitory Postsynaptic Potential Vocalization Behavior Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Presynapse Assembly Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of AMPA Receptor Activity
Pathways			Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS		Diastolic blood pressure ( 27841878) Height ( 20881960 25282103 23563607)	Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Prostate cancer ( 25217961)
Interacting Genes		12 interacting genes: CCNG1 CREBBP GATA4 GPR22 JUP MAPK14 MAPK8 MAPK9 NLGN3 NR1I2 YWHAQ YWHAZ	55 interacting genes: ALPP AP2A2 ATF4 C1orf122 C1QA CCAR2 CGB3 CTSD DLG2 DLG3 DLG4 DPEP2 EBPL EFS FANCG FBLN1 FHOD1 FKBP1A FLNA GDF15 GUK1 HID1 ITPRIP LGALS1 MAN2C1 MAP1S MEOX2 MIEN1 NFATC4 NRDC NRXN1 NRXN2 NRXN3 OAZ1 OR1F12 PKIB PLB1 PLCB4 PRDX2 PSAP PSG1 PSG11 PSG3 PSG4 PSG5 QARS1 SPAG5 SPINT1 SSR4 TNNT3 TRIM33 TXNIP UBQLN1 UBXN6 UQCRC1
Entrez ID		4776	54413
HPRD ID		09096	02275
Ensembl ID		ENSG00000100968	ENSG00000196338
Uniprot IDs		Q14934	B7Z3P8 Q4G160 Q6MZK0 Q9NZ94 X5D2P6 X5D7L6 X5DNV3
PDB IDs		2YRP
Enriched GO Terms of Interacting Partners?
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