NEK3 and PRLR

Data Source:
HPRD (in vivo)

		NEK3	PRLR
Description		NIMA related kinase 3	prolactin receptor
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Axon	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Endosome Lumen Receptor Complex
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Cytokine Receptor Activity Leukemia Inhibitory Factor Receptor Activity Oncostatin-M Receptor Activity Prolactin Receptor Activity Ciliary Neurotrophic Factor Receptor Binding Protein Binding Peptide Hormone Binding Cytokine Binding Metal Ion Binding
	Biological Process	Mitotic Cell Cycle Protein Phosphorylation Cell Division	Steroid Biosynthetic Process Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Embryo Implantation Lactation Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Prolactin Signaling Pathway Oncostatin-M-mediated Signaling Pathway Activation Of Janus Kinase Activity Negative Regulation Of Apoptotic Process Leukemia Inhibitory Factor Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cold-induced Thermogenesis
Pathways			Prolactin receptor signaling Prolactin receptor signaling Growth hormone receptor signaling
Drugs		Fostamatinib	Somatotropin
Diseases
GWAS			Advanced age-related macular degeneration ( 26691988) Chronotype ( 30696823) Metabolite levels ( 23823483) Paneth cell defects in Crohn's disease ( 28352666) Psychotic experience ( 31553412) Response to lurasidone in schizophrenia ( 29730043)
Interacting Genes		6 interacting genes: BPGM CDCA8 NMNAT1 PRLR VAV1 VAV2	20 interacting genes: CISH CREBBP CSH1 FBXW11 GH1 INSIG2 JAK2 NEK3 PLPP6 PPIA PRL PTPN11 SOCS2 SOCS3 TEC VAV1 VAV2 YWHAG YWHAZ ZAP70
Entrez ID		4752	5618
HPRD ID		04954	01457
Ensembl ID		ENSG00000136098	ENSG00000113494
Uniprot IDs		P51956 Q6ZN64	P16471
PDB IDs			1BP3 2LFG 2N7I 3D48 3MZG 3N06 3N0P 3NCB 3NCC 3NCE 3NCF 4I18
Enriched GO Terms of Interacting Partners?
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