NEK2 and DUSP10

Data Source:
HPRD (in vivo)

		NEK2	DUSP10
Description		NIMA related kinase 2	dual specificity phosphatase 10
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GO Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Condensed Nuclear Chromosome Spindle Pole Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome Cytosol Microtubule Midbody Protein-containing Complex	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Nuclear Speck
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Phosphatase Binding Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/threonine Phosphatase Activity JUN Kinase Binding Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity MAP Kinase Phosphatase Activity Mitogen-activated Protein Kinase P38 Binding Mitogen-activated Protein Kinase Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Mitotic Sister Chromatid Segregation G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Blastocyst Development Protein Phosphorylation Chromosome Segregation Regulation Of Mitotic Nuclear Division Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of DNA Binding Regulation Of Mitotic Centrosome Separation Protein Autophosphorylation Spindle Assembly Centrosome Separation Cell Division Meiotic Cell Cycle Positive Regulation Of Telomerase Activity Regulation Of Attachment Of Spindle Microtubules To Kinetochore Mitotic Spindle Assembly Ciliary Basal Body-plasma Membrane Docking Negative Regulation Of Centriole-centriole Cohesion Positive Regulation Of Telomere Capping	Inactivation Of MAPK Activity Regulation Of Adaptive Immune Response Protein Dephosphorylation Negative Regulation Of Epithelial Cell Migration Dephosphorylation Negative Regulation Of Cell Migration Response To Lipopolysaccharide Peptidyl-tyrosine Dephosphorylation Peptidyl-threonine Dephosphorylation Negative Regulation Of JUN Kinase Activity Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of JNK Cascade Oligodendrocyte Differentiation Negative Regulation Of Oligodendrocyte Differentiation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Brown Fat Cell Differentiation Negative Regulation Of P38MAPK Cascade Negative Regulation Of Epithelium Regeneration Peptidyl-tyrosine Dephosphorylation Involved In Inactivation Of Protein Kinase Activity
Pathways		APC-Cdc20 mediated degradation of Nek2A Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	RAF-independent MAPK1/3 activation Negative regulation of MAPK pathway Signaling by MAPK mutants
Drugs		5-[(Z)-(5-Chloro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-N,2,4-trimethyl-1H-pyrrole-3-carboxamide Fostamatinib
Diseases
GWAS		Red cell distribution width ( 32888494 27863252 28957414)	Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Colorectal cancer ( 25990418 20972440 24836286 29471430) Colorectal cancer or advanced adenoma ( 30510241) Copper levels ( 26025379) Lung function (FEV1) ( 30061609) Lung function (FVC) ( 30061609) Progressive supranuclear palsy ( 30089514) Serum thyroid-stimulating hormone levels ( 25436638) Tonsillectomy ( 27182965 28928442) White matter lesion progression ( 26451028) White matter lesion progression (adjusted for white matter lesion burden at baseline) ( 26451028)
Interacting Genes		28 interacting genes: CCDC85A CDC20 CEP250 CHGA CSN2 CTNNB1 DCTN1 EDRF1 EIF4A2 FZR1 GIT1 IFT140 IMMT MAD1L1 MAPK1 MCC NDC80 NEK11 PDE4DIP PPP1CA PPP1CC PPP1R2 PRKN PTPRD SMURF1 SPTBN4 TCF25 TPM3	20 interacting genes: CMTM6 ERBB4 FHL2 FN1 FNDC3B HOXA1 HTT IGF1R KRTAP3-2 MAPK10 MAPK11 MAPK14 MAPK3 MAPK8 MAPK9 PTK7 ROR2 RPS11 SLX1B SNX2
Entrez ID		4751	11221
HPRD ID		04953	12320
Ensembl ID		ENSG00000117650	ENSG00000143507
Uniprot IDs		F6U4U2 P51955	Q9Y6W6
PDB IDs		2JAV 2W5A 2W5B 2W5H 2WQO 2XK3 2XK4 2XK6 2XK7 2XK8 2XKC 2XKD 2XKE 2XKF 2XNM 2XNN 2XNO 2XNP 4A4X 4AFE 5M51 5M53 5M55 5M57 6SGD 6SGH 6SGI 6SGK 6SK9 6TM5	1ZZW 2OUC 2OUD 3TG1 6MC1
Enriched GO Terms of Interacting Partners?
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