NDUFB9 and EYA1

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)

		NDUFB9	EYA1
Description		NADH:ubiquinone oxidoreductase subunit B9	EYA transcriptional coactivator and phosphatase 1
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex I	Nucleus Nucleoplasm Cytoplasm Nuclear Body
	Molecular Function	Protein Binding NADH Dehydrogenase (ubiquinone) Activity	Protein Tyrosine Phosphatase Activity Protein Binding Metal Ion Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Mitochondrial Electron Transport, NADH To Ubiquinone Sensory Perception Of Sound Mitochondrial Respiratory Chain Complex I Assembly	Double-strand Break Repair Sensory Perception Of Sound Anatomical Structure Morphogenesis Response To Ionizing Radiation Histone Dephosphorylation Protein Sumoylation Cell Differentiation Peptidyl-tyrosine Dephosphorylation Ear Morphogenesis Positive Regulation Of DNA Repair Anatomical Structure Development Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Respiratory electron transport Complex I biogenesis	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Drugs		NADH
Diseases			Contiguous gene deletion syndrome involving EYA1, including: Oto-facio-cervical syndrome (OFC); Branchiootic syndrome 1 (BOS1); Branchio-oto-renal syndrome (BOR)
GWAS			Adolescent idiopathic scoliosis ( 30395268) Chin dimples ( 27182965) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Heel bone mineral density ( 30598549 28869591) Hypospadias ( 25108383) Longevity (85 years and older) ( 24688116) Paneth cell defects in Crohn's disease ( 28352666) Sleep-related phenotypes ( 17903308) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 28448500)
Interacting Genes		11 interacting genes: ELP1 FEZ1 GDF9 HAP1 IMMT MAGEA11 MEF2A RBBP6 SH3GL3 UBC XRN1	8 interacting genes: DACH1 GNAI2 GNAZ GSK3B H2AX SIX1 SIX2 SIX3
Entrez ID		4715	2138
HPRD ID		03264	03388
Ensembl ID		ENSG00000147684	ENSG00000104313
Uniprot IDs		E9PH64 Q9Y6M9	A0A024R813 A0A2R8Y6K4 A6NCB9 B3KXR1 F8WB53 Q0P517 Q99502
PDB IDs		5XTC 5XTD 5XTH 5XTI
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?