EYA1 and SIX2

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, two hybrid, in vivo)

		EYA1	SIX2
Description		EYA transcriptional coactivator and phosphatase 1	SIX homeobox 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Body	Chromatin Nucleus Transcription Regulator Complex
	Molecular Function	Protein Tyrosine Phosphatase Activity Protein Binding Metal Ion Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein-containing Complex Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Double-strand Break Repair Sensory Perception Of Sound Anatomical Structure Morphogenesis Response To Ionizing Radiation Histone Dephosphorylation Protein Sumoylation Cell Differentiation Peptidyl-tyrosine Dephosphorylation Ear Morphogenesis Positive Regulation Of DNA Repair Anatomical Structure Development Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Kidney Development Chondrocyte Differentiation Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Regulation Of Transcription By RNA Polymerase II Protein Import Into Nucleus Mesodermal Cell Fate Specification Cell Population Proliferation Anatomical Structure Morphogenesis Anterior/posterior Axis Specification Cell Migration Regulation Of Ossification Regulation Of Chondrocyte Differentiation Middle Ear Morphogenesis Negative Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Embryonic Digestive Tract Morphogenesis Embryonic Cranial Skeleton Morphogenesis Nephron Development Nephron Morphogenesis Mesenchymal Stem Cell Maintenance Involved In Nephron Morphogenesis Condensed Mesenchymal Cell Proliferation Mesenchymal Cell Differentiation Involved In Kidney Development Regulation Of Branching Involved In Ureteric Bud Morphogenesis Mesenchymal Stem Cell Proliferation Positive Regulation Of Chondrocyte Proliferation
Pathways		Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Drugs
Diseases		Contiguous gene deletion syndrome involving EYA1, including: Oto-facio-cervical syndrome (OFC); Branchiootic syndrome 1 (BOS1); Branchio-oto-renal syndrome (BOR)
GWAS		Adolescent idiopathic scoliosis ( 30395268) Chin dimples ( 27182965) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Heel bone mineral density ( 30598549 28869591) Hypospadias ( 25108383) Longevity (85 years and older) ( 24688116) Paneth cell defects in Crohn's disease ( 28352666) Sleep-related phenotypes ( 17903308) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 28448500)	Blood sugar levels ( 29403010) Clozapine-induced myocarditis in schizophrenia ( 32066683) Fasting blood glucose ( 29621232) Fasting plasma glucose ( 25187374) Glycated hemoglobin levels ( 29170429) Hemoglobin A1c levels ( 29403010) Lung cancer ( 28604730) Metabolite levels ( 21909109) Refractive error ( 32231278) Retinal arteriole-to-venule ratio ( 31597446)
Interacting Genes		8 interacting genes: DACH1 GNAI2 GNAZ GSK3B H2AX SIX1 SIX2 SIX3	8 interacting genes: APP CDKN2A CLIP4 EYA1 EYA3 TLE1 TLE3 TLE5
Entrez ID		2138	10736
HPRD ID		03388	05408
Ensembl ID		ENSG00000104313	ENSG00000170577
Uniprot IDs		A0A024R813 A0A2R8Y6K4 A6NCB9 B3KXR1 F8WB53 Q0P517 Q99502	Q8TBA2 Q9NPC8
PDB IDs
Enriched GO Terms of Interacting Partners?
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