ATIC and VWC2L

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		ATIC	VWC2L
Description		5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	von Willebrand factor C domain containing 2 like
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Membrane Extracellular Exosome	Extracellular Space AMPA Glutamate Receptor Complex Synapse
	Molecular Function	IMP Cyclohydrolase Activity Phosphoribosylaminoimidazolecarboxamide Formyltransferase Activity Protein Homodimerization Activity Cadherin Binding	Protein Binding
	Biological Process	Brainstem Development Nucleobase-containing Compound Metabolic Process 'de Novo' IMP Biosynthetic Process Nucleoside Metabolic Process Purine Ribonucleoside Monophosphate Biosynthetic Process Response To Inorganic Substance Cerebellum Development Cerebral Cortex Development Animal Organ Regeneration Dihydrofolate Metabolic Process Tetrahydrofolate Biosynthetic Process Cellular Response To Interleukin-7	Multicellular Organism Development Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Neuron Differentiation
Pathways		Purine ribonucleoside monophosphate biosynthesis
Drugs		Tetrahydrofolic acid Methotrexate Pemetrexed AICA ribonucleotide Guanosine-5'-Monophosphate 5-monophosphate-9-beta-D-ribofuranosyl xanthine Acid yellow 54 free acid N-[4-([(2-Amino-4-oxo-1,4-dihydropyrido[3,2-d]pyrimidin-6-yl)methyl]{(2E)-3-[4-carbamoyl-1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-imidazol-5-yl]-2-propenoyl}amino)benzoyl]-L-glutamic acid
Diseases		AICA-ribosiduria; ATIC deficiency
GWAS		Airway imaging phenotypes ( 26030696) Metabolite levels ( 23823483)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Degraded stimulus continuous performance test score ( 31596458) Dietary fat liking ( 32516399) Household income (MTAG) ( 31844048) Neuroticism ( 29255261) PR interval ( 23534349)
Interacting Genes		5 interacting genes: EGFR LINC01554 MTNR1A PRNP SERPINB5	27 interacting genes: C17orf50 C22orf39 CEMP1 CRCT1 CXCL5 CYSRT1 DEFB112 FBXO34 FHL3 HOXA1 KRTAP10-8 KRTAP11-1 KRTAP19-2 LCE1A LCE1C LCE3A LCE5A MEOX2 NR4A3 OTX1 PPARA RIPK4 SPATA3 TRIM42 TYRO3 YPEL3 ZNF20
Entrez ID		471	402117
HPRD ID		03434	19160
Ensembl ID		ENSG00000138363	ENSG00000174453
Uniprot IDs		P31939 V9HWH7	B2RUY7 B7ZW27
PDB IDs		1P4R 1PKX 1PL0 5UY8 5UZ0
Enriched GO Terms of Interacting Partners?
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