NDUFA5 and NDUFS3

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		NDUFA5	NDUFS3
Description		NADH:ubiquinone oxidoreductase subunit A5	NADH:ubiquinone oxidoreductase core subunit S3
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GO Annotations	Cellular Component	Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex I	Mitochondrion Mitochondrial Respiratory Chain Complex I Mitochondrial Matrix Nuclear Body Mitochondrial Membrane
	Molecular Function	Protein Binding NADH Dehydrogenase (ubiquinone) Activity	NADH Dehydrogenase Activity Protein Binding NADH Dehydrogenase (ubiquinone) Activity Electron Transfer Activity
	Biological Process	Mitochondrial Electron Transport, NADH To Ubiquinone Respiratory Electron Transport Chain Mitochondrial Respiratory Chain Complex I Assembly	Mitochondrial Electron Transport, NADH To Ubiquinone Substantia Nigra Development Negative Regulation Of Cell Growth Mitochondrial Respiratory Chain Complex I Assembly Reactive Oxygen Species Metabolic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Respiratory electron transport Complex I biogenesis	Respiratory electron transport Complex I biogenesis
Drugs		NADH	NADH
Diseases			Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS			Adult body size ( 32376654) Alcohol use disorder (total score) ( 30336701) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Bipolar disorder ( 31043756) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 20935630) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Fruit consumption ( 32066663) Height ( 28552196) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Mood instability ( 31168069) Neuroticism ( 29255261) Refractive error ( 32231278) Sleep duration (short sleep) ( 30846698)
Interacting Genes		10 interacting genes: APP CBY2 CCDC85B COG6 DAZAP2 GOLGA2 NDUFB1 NDUFS3 PLEKHF2 TTR	4 interacting genes: GZMA NDUFA5 RASL10B TMEM11
Entrez ID		4698	4722
HPRD ID		03398	10355
Ensembl ID		ENSG00000128609	ENSG00000213619
Uniprot IDs		A0A024R745 A0A087WXR5 A0A087X1G1 Q16718	O75489
PDB IDs		5XTB 5XTD 5XTH 5XTI	5XTB 5XTD 5XTH 5XTI
Enriched GO Terms of Interacting Partners?
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